摘要
目的:综述脂质聚合物杂化纳米粒的最新研究进展。方法:查阅近20年国内外有关脂质聚合物杂化纳米粒文献,对脂质聚合物杂化纳米粒的制备方法、主要影响因素及其应用现状进行总结。结果:核壳结构脂质聚合物杂化纳米粒兼具脂质体与聚合物纳米粒2种载体的优势,可一定程度改善脂质体和纳米粒存在的稳定性差、药物渗漏等不足。结论:脂质聚合物杂化纳米粒是一种性能优良,具有广阔发展前景的新型给药系统,但目前尚需对稳定性、在体药效及安全性等问题做深入研究。
OBJECTIVE To review the latest research progress of the lipid-polymer hybrid nanoparticles（LPHNPs）.METHODS According to the recent relevant literature,the preparations for the LPHNPs,characterization analysis,drug incorporation,drug release,and its application in the pharmaceutical field were summarized.RESULTS LPHNPs have core-shell structures,which exhibit complementary characteristics of both polymeric nanoparticles and liposomes,and it can ameliorate problems to a certain extent,such as poor stability and drug leakage.CONCLUSION Lipid polymer hybrid nanoparticle is a new type of drug delivery system with good properties and broad prospects.However,it is necessary to intensively study the stability,in vivo efficacy and safety of the nanoparticles.
作者
穆珺
王春柳
刘洋
张红
孙婷婷
马虎强
李晔
MU Jun1 , WANG Chun-liu2, LIU Yang2, ZHANG Hong2, SUN Ting-ting2, MA Hu-qiang1, LI Ye2(1. Shaanxi University of Chinese Medicine, Shaanxi Xianyang 712046, China; 2. Shaanxi Academy of Traditional Chinese Medicine, Shaanxi Xi＇an 710003, Chin)
出处
《中国医院药学杂志》
CAS
北大核心
2018年第8期891-896,共6页
Chinese Journal of Hospital Pharmacy
基金
陕西省科技统筹创新工程计划项目(编号:2016KTCL03-14)
关键词
脂质聚合物杂化纳米粒
给药系统
研究进展
lipid polymer hybrid nanoparticles
drug delivery systems
research progress
