摘要
目的探讨血清甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、谷氨酰转肽酶(GGT)、D-二聚体(D-D)联合检测对原发性肝癌的诊断价值。方法采用回顾性研究方法对该院68例原发性肝癌患者(肝癌组),79例代偿性肝硬化患者(肝硬化组),70例同期该院体检健康者(健康对照组)纳入研究。检测3组研究对象AFP、AFU、GGT、D-D水平和阳性检出率并进行比较,评估AFP、AFU、GGT、D-D单独检测和联合检测对原发性肝癌的诊断效率。结果肝癌组患者AFP、AFU、GGT、D-D水平、单项检测阳性率、联合检测阳性率均明显高于肝硬化组和健康对照组,差异均有统计学意义(P<0.05),且肝硬化组也高于健康对照组(P<0.05)。AFP、AFU、GGT、D-D联合检测提高了原发性肝癌检测的敏感性和阴性预测值(P<0.05)。结论AFP、AFU、GGT、D-D联合检测可提高原发性肝癌检测的敏感性和特异性,具有较高的临床应用价值。
Objective To explore the value of combined testing ofα-fetoprotein（AFP）,α-L-fucosidase（AFU）,glutamyl transpeptidase（GGT）,D-Dimer（D-D）in primary hepatic cancer diagnosis.Methods Retrospective study was adopted.A total of 68 primary hepatic cancer patients（PHC group）,79 compensated cirrhosis patients（cirrhosis group）and 70 health individuals（control group）were enrolled.AFP,AFU,GGT and D-D were assessed and compared between 3 groups.The effectiveness of single tests and combined test was further evaluated.Results The AFP,AFU,GGT and D-D expression level,positive rates of single tests,positive rate of combined test in PHC group and Cirrhosis group were significantly higher than Control group（P〈0.05）,and these results were also significantly higher in Cirrhosis group than control group（P〈0.05）.Sensitivity and negative predictive value of primary hepatic cancer diagnosis were improved in combined test of AFP,AFU,GGT and D-D.Conclusion Combined test of AFP,AFU,GGT and D-D can increase the sensitivity and specificity of primary hepatic cancer diagnosis,and shows important clinical value.
作者
黄裔程
HUANG Yicheng(Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China)
出处
《检验医学与临床》
CAS
2018年第10期1408-1410,共3页
Laboratory Medicine and Clinic
