摘要
目的观察术前调强放疗联合同步替吉奥化疗对局部晚期直肠癌患者治疗效果的影响。方法选择2015年5月至2017年8月我院收治的50例局部晚期直肠癌患者,随机分为对照组(n=25)与观察组(n=25)。对照组进行常规手术治疗,观察组进行术前调强放疗联合同步替吉奥化疗后手术治疗,观察两组患者的近期疗效、保肛率及不良反应发生率。结果观察组的近期总有效率为88.0%,保肛率为88.0%,显著高于对照组的48.0%、40.0%,差异具有统计学意义(P<0.05);两组患者的不良反应发生率无显著差异(P>0.05)。结论术前调强放疗联合同步替吉奥化疗应用于局部晚期直肠癌患者,近期效果显著,患者保肛率提高,具有较高的临床推广价值。
Objective To observe the influence of preoperative intensity modulated radiation therapy （IMRT） combined with synchronous tegafur gimeracil oteracil potassium capsule chemotherapy （TGOPC） on the therapeutic effect of patients with local advanced rectal cancer. Methods 50 cases of patients with local advanced rectal cancer admitted to our hospital from May 2015 to August 2017 were selected and randomly divided into two group, with 25 cases in each group. The control group was treated with routine surgery, while the observation group was treated with 1MRT combined with synchronous TGOPC before surgery. The short-term efficacy, the sphincter-saving rate and the incidence of adverse reactions of patients in the two groups were observed. Results The total short-term effective rate and sphincter-saving rate of the observation group were 88.0% and 88.0% respectively, significantly higher than 48.0% and 40.0% of the control group, respectively （P 〈0.05）. No significant difference was found between the two groups in the incidence of adverse reactions （P 〉0.05）. Conclusions IMRT combined with synchronous TGOPC before surgery has a significant short-terra effect and higher sphincter-saving rate for patients with local advanced rectal cancer, which is of high clinical application value.
作者
汤忠明
郭恒照
黄乃信
汪娇玲
易正生
TANG Zhongming;GUO Hengzhao;HUANG Naixin;WANG Jiaoling;YI Zhengsheng(Zhongshan Chen Xinghai Hospital, Zhongshan 528415, China)
出处
《临床医学工程》
2018年第4期491-492,共2页
Clinical Medicine & Engineering
关键词
调强放疗
替吉奥化疗
直肠癌
疗效
Intensity modulated radiation therapy （IMRT）
Tegafur gimeracil oteracil potassium capsule chemotherapy （TGOPC）
Rectal cancer
Therapeutic effect
