摘要
巴戟天药用历史悠久,具有广泛的药用价值,为临床常用中药之一。现代研究表明低聚糖类成分是巴戟天中的主要药效物质,具有抗痴呆、抗抑郁、抗氧化应激、提高学习记忆能力、增强免疫力及性功能等作用,上述药理作用均具有较高的开发利用价值。通过查阅大量文献资料,发现巴戟天的许多临床疗效均与其低聚糖类成分的药理作用有关,这些药理作用也科学地诠释了中药巴戟天补肾、主骨、益脑的传统功效。因此,国内外学者对巴戟天低聚糖类成分做了大量的实验研究工作,尤其是巴戟天低聚糖对神经系统保护作用方面的研究,相关研究结果显示其抗痴呆、抗抑郁、提高学习记忆等活性显著,具有开发成治疗神经退行性疾病药物的潜力。笔者通过检索中国知网,万方,Pub Med,Science Direct,Springer等数据库,对近20年关于巴戟天低聚糖类化学成分的提取纯化工艺、成分检测方法、药理作用及机制等方面的研究,进行了整理和总结,分析其研究和开发前景,系统地综述了巴戟天低聚糖类成分的研究进展,以期为巴戟天低聚糖的深入研究和开发利用提供理论参考。
Morindae Officinalis Radix has a long history of medicinal use in China.It has a wide range of medicinal value and is one of the most commonly used traditional Chinese medicines in clinical application.According to modern studies,oligosaccharides are the main effective components in Morindae Officinalis Radix,with many functions such as anti-dementia,anti-depression,anti-oxidative stress,improving learning and memory ability,and enhancing immunity and sexual function.The above pharmacological actions are of great value for development and utilization.By consulting massive literature materials,it was found that many clinical effects of Morindae Officinalis Radix were correlated with the pharmacological actions of the oligosaccharides.These pharmacological actions have also scientifically interpreted the traditional functions of Morindae Officinalis Radix such as ‘tonifying kidney,dominating bone and benefiting brain＇.Therefore,scholars both at home and abroad have done a lot of research work on it,especially the studies on the protective effects of the oligosaccharides from Morindae Officinalis Radix on nervous system.Relevant results showed that it had significant effects in antidementia,anti-depression,improving the learning and memory ability,with the potential to develop drugs for the treatment of neurodegenerative disease.In this paper,the researches of the past 20 years on extraction and purification process,component detection method and pharmacological actions of oligosaccharides from Morindae Officinalis Radix were collected and summarized upon accessing multiple databases such as CNKI,Wan Fang,Pub Med,Science Direct and Springer.The researches and development prospects were also analyzed,and the research progress on oligosaccharides from Morindae Officinalis Radix was reviewed for further studying and comprehensive utilization of these oligosaccharides.
作者
卢洪梅
邓少东
卢阳佳
李玉运
何银妹
LU Hong-mei;DENG Shao-dong;LU Yang-jia;LI Yu-yun;HE Yin-mei(The Second School of Clinical Medicine, Guangdong Medical University, Dongguan 523808, China;School of Pharmacy, Guangdong Medical University, Dongguan 523808, China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第9期220-227,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81403085)
广东医学院科研基金博士学位人员科研启动项目(B2013007)
关键词
巴戟天
低聚糖
提取纯化
成分检测
药理作用
Morindae Officinalis Radix
oligosaccharides
extraction and purification
component detection
pharmacological action
