摘要
目的探讨加巴喷丁治疗躁狂发作的效果和安全性,为躁狂发作的治疗提供参考。方法于2016年1月-2017年4月在安徽省某精神病专科医院选取符合《国际疾病分类(第10版)》(ICD-10)情感障碍躁狂发作诊断标准的122例住院患者为研究对象,按照随机数字表法分为研究组(n=62)和对照组(n=60)。研究组给予加巴喷丁治疗,对照组给予碳酸锂治疗,疗程均为8周。于治疗前、治疗第1、2、4、8周采用贝克-拉范森躁狂量表(BRMS)和临床疗效总评量表(CGI)评价疗效,于治疗前、治疗第2、4、8周进行血尿常规、肝功能、肌酐/尿素氮、心电图、脑电图检测,于治疗第8周末采用副反应量表(TESS)评定安全性。结果治疗后,两组BRMS评分比较差异无统计学意义(t=-1.722~1.830,P均>0.05);研究组和对照组显效率比较差异无统计学意义(76.3%vs.79.3%,χ2=1.28,P>0.05);治疗后8周,两组BRMS和CGI评分均低于治疗前(P均<0.01);两组流涎、镇静、月经紊乱、血糖异常等不良反应比较差异有统计学意义(χ2=3.48~5.30,P均<0.05)。结论加巴喷丁与碳酸锂对躁狂发作的效果相当,但加巴喷丁的安全性更好。
Objective To explore the effect and safety of gabapentin in the treatment of manic episode and to provide references for the treatment of manic episode. Methods From January 2016 to April 2017 in a psychiatric hospital of Anhui province,122 hospitalized patients were selected,and they all met the criteria for the diagnosis of affective disorder in the International Classification of Diseases,tenth edition( ICD-10). According to the random number table method,122 patients were divided into the study group( n = 62) and the control group( n = 60). The study group was treated with gabapentin,and the control group was treated with lithium carbonate. The course of treatment was 8 weeks. Before and after treatment for 1,2,4 and 8 weeks,Bech-Rafaelsen Mania Rating Scale( BRMS) and Clinical Global Impression( CGI) were adopted to evaluate the efficacy. Routine blood and urine tests,liver function examination,creatinine/urea nitrogen,electrocardiogram and electroencephalogram were conducted before and after treatment for 2,4 and 8 weeks. At the 8 thweek of treatment,Treatment Emergent Symptom Scale( TESS) was adopted to assess the safety.Results After treatment, there was no statistically significant difference between the two groups of BRMS scores( t =-1. 722 ~ 1. 830,P > 0. 05). There was no statistically significant difference in efficiency rate between the study group and the control group( 76. 3% vs. 79. 3%,χ2= 1. 28,P > 0. 05). After 8 weeks of treatment,both BRMS and CGI scores of the two groups were lower than before treatment( P < 0. 01). Adverse reactions such as salivation,sedation,menstrual disorders and abnormal blood glucose of the two groups showed statistically significant differences( χ2= 3. 48 ~ 5. 30,P < 0. 05). Conclusion Gabapentin and lithium carbonate have the same effect on manic episodes,but gabapentin is safer.
出处
《四川精神卫生》
2018年第1期27-31,共5页
Sichuan Mental Health
关键词
躁狂发作
加巴喷丁
碳酸锂
Manic episodes
Gabapentin
Lithium carbonate
