摘要
目的探究血清转化生长因子β_1(TGF-β_1)和结缔组织生长因子(CTGF)的表达与增生性糖尿病视网膜病变(PDR)的临床关系。方法选取在河南科技大学第一附属医院就诊的2型糖尿病患者230例,依据是否合并视网膜病变,将所有患者分为PDR组和非增生性糖尿病性视网膜病变(NPDR)组,其中PDR组120例,NPDR组110例,同时选取110例健康人员作为对照组,收集整理3组患者的TGF-β_1、CTGF和其余临床资料,并进行比较。结果与NPDR组和对照组相比,PDR组的血清低密度脂蛋白水平较高(P<0.05);与NPDR组相比,PDR组的病程较长(P<0.05);PDR组的血清TGF-β_1和CTGF表达水平高于NPDR组和对照组(P<0.05),NPDR组与对照组的血清TGF-β_1、CTGF表达水平比较,差异无统计学意义(P>0.05)。结论PDR患者血清TGF-β_1、CTGF表达水平较高,与PDR的发病具有一定相关性。
Objective To explore the clinical relationships of serum expressions of transforming growth factor （TGF-β1） and connective tissue growth factor （CTGF） with proliferative diabetic retinopathy （PDR）. Methods A total of 230 patients with type 2 diabetes in our hospital from August 2013 to November 2015 were selected, and divided into the PDR group （120 cases） and the NPDR group （110 cases） according to whether they had retinopathy or not, then 110 healthy people were chosen as the control group. Serum TGF-β1 and CTGF and other clinical data of the three groups were collected, sorted and compared. Results Compared to the NPDR group and the control group, the serum level of low-density lipoprotein in the PDR group was significantly higher （P 〈 0.05）. Compared to the NPDR group, the course of disease in the PDR group was significantly higher （P 〈 0.05）. The serum levels of TGF-β1 and CTGF in the PDR group were signifcantly higher than those in the NPDR group and the control group （P 〈 0.05）, but there were no signifcant differences between the NPDR group and the control group （P 〉 0.05）. Conclusions Serum levels of TGF-β1 and CTGF are higher in the patients with PDR. And they have certain correlations with the onset and course of PDR.
出处
《中国现代医学杂志》
CAS
2018年第7期61-65,共5页
China Journal of Modern Medicine
