摘要
目的评估前列腺特异性抗原(PSA)相关标志物对高原地区PSA>4.0μg/L藏族人群前列腺癌(PCa)的诊断价值。方法回顾性分析2014年10月~2016年10月西藏自治区人民医院泌尿外科就诊的110例PSA>4.0μg/L的藏族人群前列腺穿刺的病理结果,年龄50~100岁,将患者按PSA含量4.1~10.0μg/L、10.1~20.0μg/L、20.1~50.0μg/L、>50.0μg/L分为4组;同时将年龄分为4组:50~59岁、60~69岁、70~79岁、≥80岁,评价游离前列腺特异性抗原/总前列腺特异性抗原(f-PSA/t-PSA)、前列腺特异性抗原密度(PSAD)诊断不同PSA水平下藏族人前列腺癌的价值及不同年龄段不同PSA水平下藏族人PCa的检出率。结果 110例患者中PCa检出率9.1%(10/110)。PSA含量4.1~10.0μg/L、10.1~20.0μg/L、20.1~50.0μg/L、>50.0μg/L时PCa的检出率分别是:1.8%(1/55)、3.8%(1/26)、4.8%(1/21)、87.5%(7/8);f-PSA/t-PSA、PSAD在前列腺癌与非前列腺癌患者之间差异具有统计学意义(P<0.05),但在不同的PSA区间内因PCa样本数量太少,无法进行比较;而各个年龄段的检出率比较差异无统计学意义。结论 PSA>4.0μg/L的藏族人群中f-PSA/t-PSA、PSAD能有效诊断前列腺癌,但特异性不高。
Objective To evaluate prostate-specific antigen(PSA) related markers in the diagnosis of prostate cancer(PCa) with PSA>4.0 μg/L in Tibetan population at high altitude in Lasa. Methods We reviewed the prostate biopsy examination data of Tibetan population from October 2014 to October 2016, a total of 110 subjects with PSA>4.0 μg/L, aged 50-100 years. According to the levels of PSA, the subjects were divided into four groups: 4.1-10.0 μg/L, 10.1-20.0 μg/L, 20.1-50.0 μg/L, >50.0 μg/L.The diagnostic values of free/total(f-PSA/t-PSA) and PSA density(PSAD) were assessed in different PSA levels. According to the age, the subjects were divided into four groups: 50-59 yr, 60-69 yr, 70-79 yr, ≥80 yr. The rates of PCa detection with different PSA levels were assessed in different age groups. Results The rates of PCa detection is 9.1%(10/110) in these 110 subjects, with detection rates of 1.8%(1/55), 3.8%(1/26), 4.8%(1/21), 87.5%(7/8) in these different PSA levels of 4.1-10.0 μ g/L, 10.1-20.0 μg/L, 20.1-50.0 μg/L, >50.0 μg/L. There were significant difference in f-PSA/t-PSA and PSAD between the PCa patients and non-PCa patients(P<0.05). But the PCa patients in different PSA levels were too little to compare with f-PSA/t-PSA or PSAD; there were no significant difference in different age groups. Conclusion f-PSA/t-PSA and PSAD can effective diagnosis of PCa with the PSA>4.0 μg/L, but the specificity is not enough.
出处
《当代医学》
2018年第5期7-9,共3页
Contemporary Medicine
关键词
前列腺癌
前列腺特异性抗原
年龄
藏族人群
Prostate cancer
Prostate-specific antigen
Age
Tibetan population
