摘要
目的研究原发性肾病综合征患儿血脂代谢及脂质三角的变化及其临床意义。方法分析我科收治的46例原发性肾病综合征患儿治疗前后血脂水平及脂质三角的变化。结果原发性肾病综合征患儿与正常健康体检儿童32例比较,血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇均明显增高,血清高密度脂蛋白变化不明显,但差异有统计学意义(P<0.05),肾病综合征患儿治疗前后,敏感型经治疗后血脂总胆固醇、甘油三酯、低密度脂蛋白胆固醇均明显下降(P<0.05),非激素敏感型治疗后血脂总胆固醇、甘油三酯、低密度脂蛋白胆固醇改变不明显(P>0.05)。原发性肾病综征与正常对照组脂质三角有明显异常(P<0.01),经糖皮质激素治疗后,敏感型治疗后脂质三角恢复正常(P<0.01),非激素敏感型治疗后脂质三角仍存在异常(P>0.05)。结论原发性肾病综合征患儿血脂代谢发生异常,脂质三角出现明显变化。对原发性肾病综征血脂持续增高的患儿,应给予低脂饮食,血管紧张素转化酶抑制剂,必要时予降脂治疗。
Objective To study the changes .of blood lipid metabolism and lipid triangle in children with Primary Nephrotie Syndrome （PNS）. Methods Before and after treatment, 46 eases of children with primary nephrotic syndrome in changes of blood lipid level and lipid trigonometry were analyzed. Results Compared with 32 normal healthy children, serum total cholesterol, triglyeeride and low density lipoprotein cholesterol in primary nephrotic syndrome children were significantly increased, and the changes in serum HDL were not significant, but the difference was statistically significant （P 〈 0.05）. Before and after treatment, the total cholesterol, triglyceride and low density lipoprotein cholesterol were significantly decreased in children with nephrotie syndrome （P 〈 0.05）. The changes of total cholesterol, triglyceride and low density lipoprotein cholesterol were not significant after non hormone sensitive treatment （P 〉 0.05）. There were obvious abnormalities in the lipid trigonometry of the primary nephrotic syndrome and the normal control group （P 〈 0.01）. After treatment with glueocorticoid, the lipid trigonometry was restored to normal after sensitive treatment （P 〈 0.01）. There were still abnormalities in the lipid trigonometry after non hormone sensitive treatment （P 〉 0.05）. Conclusion The lipid metabolism in children with primary nephrotic syndrome is obviously abnormal, there were significant changes in the lipid trigonometry. A low fat diet, angiotensin converting enzyme inhibitor should be given to children with primary nephrotic syndrome, which should be treated with lipid-lowering when necessary.
出处
《中国卫生标准管理》
2017年第27期25-26,共2页
China Health Standard Management
