摘要
随着精准医疗在肿瘤临床领域中的广泛开展,对肿瘤分子生物学特性进行实时动态监测的需求越来越高。近年来,液体活检以简便快捷、微创、实时、特异性高和克服时空异质性等特点在肿瘤临床诊断与治疗中发挥着越来越重要的价值。本文围绕液体活检的两种主要技术:循环肿瘤细胞和循环肿瘤DNA检测技术的特点,介绍了其在结直肠癌精准医疗领域的最新研究进展,探讨了面临的挑战和可行的解决方案。
With the rapid development of precision medicine in cancer,the demand for dynamic monitoring of tumor molecular characteristic has been increased.In recent years,liquid biopsy is currently playing a more and more important role in diagnosis and treatment of cancer in clinical practice due to its convenience,non-invasiveness,high specificity and overcoming temporal-spatial heterogeneity.This reviewintroduces circulating tumor cell（CTC） and circulating tumor DNA（ctDNA） as the most important technique in liquid biopsy,mainly focusing on their technological feature,especially recent research progress in colorectal cancer.Further,the challenge and possible solution are discussed in the clinic application of liquid biopsy.
出处
《首都医科大学学报》
CAS
北大核心
2017年第6期785-789,共5页
Journal of Capital Medical University
基金
国家科技支撑计划课题(2015BAI13B)
北京市卫生系统高层次卫生技术人才培养计划资助项目(2015-3-005)~~
关键词
液体活检
结直肠癌
循环肿瘤细胞
循环肿瘤DNA
liquid biopsy
colorectal cancer
circulating tumor cells
circulating tumor DNA
