摘要
随着现代社会越来越多的女性推迟生育年龄和二胎政策全面放开,高龄生育问题给生殖领域和妇产科带来了前所未有的挑战。尤其是受年龄影响,因卵巢逐渐衰老导致女性生育力下降的问题倍受关注。近年来,自噬作为衰老过程中一种重要的调节机制成为了新的研究热点,多项研究中已证明了增强自噬可以延缓衰老,同时也有研究发现在卵泡的形成,发育及闭锁的环节中都有细胞自噬参与的现象,颗粒细胞中自噬过程也是相对活跃的。因此,细胞自噬可能对女性生殖功能有着重要影响。通对细胞自噬与卵巢衰老之间的微观联系研究,为补肾中药改善卵巢功能和延缓卵巢衰老提供新的理论依据。
With the development of modern society, more and more women delay childbearing age, and two - child policy fully liberalized, the elderly fertility problems have brought hitherto unknown challenge to the field of reproductive and obstetrics. Especially affected by age, ovarian aging which leads to female fertility decline has attracted much atten- tion. Recently, autophagy as an important regulation mechanism of the aging process has become a new research hotspot. A number of studies have proved that enhancing autophagy can delay aging. Studies have found cell autophagy is involved in the formation, development and atresia of the follicle. The phenomenon of autophagy process is relatively active in the granular cell. The cell autophagy may have important influence on female reproductive function. This article is based on filling kidney qi and cell autophagy and microscopic contact between ovarian aging, hoping to provide new theoretical ba- sis of TCM drugs for improving ovarian function and delaying ovarian senescence.
出处
《中华中医药学刊》
CAS
北大核心
2017年第12期3117-3120,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81173289)
