摘要
目的探讨间苯三酚联用依替米星对急性胃肠炎痉挛性腹痛(AGSAP)患者疼痛症状及炎症因子水平的影响。方法 2011年3月至2016年3月在我院接受治疗的144例AGSAP患者。按数字随机表法分成观察组和对照组各72例,对照组予乳酸左氧氟沙星氯化钠注射液及盐酸消旋山莨菪碱治疗,观察组予硫酸依替米星氯化钠注射液及注射用间苯三酚治疗,对比两组临床症状缓解时间,视觉模拟评分法(VAS)评分及白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平。结果观察组腹痛、腹泻、恶心呕吐及发热缓解时间均少于对照组(P<0.05)。两组治疗1 h后及治疗完成后的VAS评分均低于治疗前,且观察组低于对照组(P<0.05)。两组治疗结束后IL-6及IL-8水平均低于治疗前(P<0.05)。且观察组低于对照组(P<0.05)。结论间苯三酚联合依替米星用于治疗AGSAP,能够有效改善患者的疼痛症状及炎症因子水平,值得推广。
Objective To investigate the effect of phloroglucinol combined with etimicin for patients with acute gastroenteritis spastic abdominal pain （AGSAP） on VAS score and inflammatory factors. Methods From March 2011 to March 2016 ,our hospital received 144 patients with AGSAP. The patients were randomly divided into observation or control group,72 in each group. The control group was given a treatment of levofloxacin lactate NaC1 injection and raeeanisodamine hydrochloride while the observation group was treated with sulfuric acid to replace levofloxacin lactate NaCl injection plus phloroglucinol injection. The relief time of clinical symp- toms, visual analogue scale （VAS） score, and levels of inflammatory factors such as interleukin-6 （IL-6） and interleukin-8 （IL-8） were compared between the two groups. Results The remission time of abdominal pain, diarrhea, nausea and vomiting as well as fever symptoms in the observation group were significantly shorter than that in the control group （ P 〈 0. 05 ）. After treatment, the VAS scores of the two groups were significantly lower than before treatment （ P 〈 0. 05 ）. The VAS scores of the observation group after 1 h treatment were significantly lower than that of the control group （ P 〈 0. 05 ）. The levels of IL-6 and IL-8 in the two groups after the treatment were significantly lower than before treatment （P 〈 0. 05 ）. After treatment, the average levels of IL-6 and IL-8 in the observation group were significantly lower than that in the control group （ P 〈 0. 05 ）. Conclusion The combination of phloroglucinol with etimiein in the treatment of patients with AGSAP can effectively improve the patient＇s symptoms of pain and inflammatory factors. It is worth of promotion.
出处
《实用医院临床杂志》
2017年第6期176-178,共3页
Practical Journal of Clinical Medicine
