摘要
目的检测M2型巨噬细胞在食管鳞状细胞癌(ESCC)中浸润和患者预后及临床病理参数的相关性。方法应用免疫组织化学Envision二步法检测M2型巨噬细胞在ESCC及癌旁正常组织中的浸润。结果食管癌组织中CD163阳性M2型巨噬细胞浸润率明显高于癌旁组织,差异有统计学意义(P<0.05)。CD163阳性M2型巨噬细胞浸润与肿瘤淋巴结转移及T分期明显相关(P<0.05);与性别、年龄、肿瘤大小和临床分期无明显相关性(P>0.05)。生存分析结果显示,CD163阳性M2型巨噬细胞浸润与患者预后明显相关(P<0.05)。结论CD163阳性M2型巨噬细胞浸润与ESCC淋巴结转移及T分期有关,且影响患者预后,其细胞浸润可能作为判断ESCC预后的指标。
Objective To investigate the infiltration of CD163 positive M2 macrophages in human esophageal squamous cell carcinoma(ESCC)and their correlation with prognosis and clinical pathological parameters.Methods The infiltration of CD163 positive M2 macrophages in ESCC and adjacent carcinoma tissue(ACT)was detected by immunohistochemistry.Results The expression rates of CD163 positive M2 macrophages were significantly higher than those in the ACT group(P <0.01).The infiltration of CD163 positive M2 macrophages significantly associated with lymph node metastasis and T classification(P <0.05).There was no correlations between CD163 positive M2 macrophages invasion and age,gender,tumor size and clinical stage(P >0.05).The survival curve analysis revealed that CD163 positive M2 macrophages infiltration significantly correlated with prognosis(P <0.05).Conclusion The infiltration of CD163 positive M2 macrophages in esophageal cancer tissues had significant correlation with lymph node metastasis,T classification and prognosis,suggesting that CD163 positive M2 macrophages might be used as a potential prognostic marker in ESCC.
出处
《新疆医科大学学报》
CAS
2017年第11期1380-1382,1387,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金(U1603284
U1303321)
新疆维吾尔自治区重大科技专项计划(201430123-1)
新疆重大疾病重点实验室开放课题(SKLIB-XJMDR-2016)
