摘要
The identification of sensitive and specific biomarkers for Parkinson＇s disease （PD） poses an impor- tant clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD. However, questions remain, such as the relationship between nigral iron and clinical indices of PD （motor impairment or disease duration）. Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging （MRI） allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics： the technological develop- ment of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives.
The identification of sensitive and specific biomarkers for Parkinson＇s disease （PD） poses an impor- tant clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD. However, questions remain, such as the relationship between nigral iron and clinical indices of PD （motor impairment or disease duration）. Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging （MRI） allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics： the technological develop- ment of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives.
基金
supported by the 13th Fiveyear Plan for the National Key Research and Development Program of China (2016YFC1306600)
the Fundamental Research Funds for the Central Universities of China (2017XZZX001-01)
the 12th Fiveyear Plan for the National Science and Technology Supporting Program of China (2012BAI10B04)
the National Natural Science Foundation of China (81571654, 81371519, and 81301190)
