摘要
微生物细胞间通过信号分子进行信息交流的现象即群体感应(Quorum sensing,QS),QS广泛存在于微生物群体中,且可以调控特定基因尤其是很多致病基因的表达。群体感应淬灭(Quorum quenching,QQ)是基于群体感应现象提出的新型病害防治策略,即通过抑制信号分子的合成、监测或对信号分子进行酶降解、修饰的途径来干扰群体感应以达到防治病害的目的。利用群体感应淬灭酶(Quorum quenching enzymes)降解微生物信号分子,是目前毒性最小、最为有效的群体感应淬灭途径。迄今为止,多种细菌信号分子的群体感应淬灭酶都已有报道,其中,酰基高丝氨酸内酯(N-acyl homoserine lactones,AHLs)和顺-11-甲基-2-癸烯酸(cis-11-Methyl-2-dodecenoic acid)群体感应淬灭酶研究最为深入。综述并分析了群体感应淬灭酶及其病害防治的研究现状、存在的问题和未来研究方向,为今后发展新型绿色安全病害防控措施提供关键理论和技术支撑。
The phenomenon of information exchanging through signal molecules between microbial cells is the Quorum Sensing（QS）.QS is widely present in microorganisms,and can modulate the expression of specific genes,especially virulence factors in pathogenicmicroorganisms. Quorum Quenching（QQ）is a new therapeutic strategy of plant diseases based on QS. QQ can be achieved by interfering QSfrom inhibiting the synthesis or detection of the signal molecules,or by enzyme-catalyzed degradation or modification of the signal molecules.Degrading signal molecules by using QQ enzymes is one of the most effective and nontoxic ways of QQ. So far,QQ enzymes of various microbialsignaling molecules have been reported,especially N-acyl homoserine lactones（AHLs）and cis-11-methyl-2-dodecenoic acid were deeplyinvestigated. In this review,we summarize and analyze the research status,deficiencies and the future development of QQ enzymes and theircontrol of plant diseases,for laying a solid foundation for developing new,green and safe measures of disease control.
出处
《生物技术通报》
CAS
CSCD
北大核心
2017年第10期80-87,共8页
Biotechnology Bulletin
基金
国家重点基础研究发展计划(2015CB150600)
广东省杰出青年科学基金(2015A030306038)
广东省高校青年创新人才项目(2014KQNCX036)
