摘要
目的:探讨糖尿病前期患者血清1,5脱水山梨醇水平变化的临床意义。方法:随机选取2016年1月-2016年6月我院内分泌门诊就诊、住院患者及体检中心体检者共153例。空腹血糖受损组(IFG)40例,糖耐量受损组(IGT)43例,IFG+IGT组35例,健康对照组(NC)35例。观察他们空腹血糖(FPG)、糖耐量后2小时血糖(2h PG)、糖化血红蛋白(HbA1c)、血清1,5-AG水平、空腹胰岛素(FINS),计算稳态模型胰岛素抵抗指数HOMA-IR。结果:健康对照组1,5-AG水平明显高于糖尿病前期各组,P<0.05,有统计学意义;对照组和糖尿病前期各组FPG、HbA1c比较没有明显的差异性,P>0.05,无统计学意义;糖尿病前期各组中1,5-AG水平与FPG、HbA1c、HOMA-IR呈显著负相关(P<0.001),FPG、HbA1c与HOMA-IR呈正相关(P<0.05)。结论:1,5-AG水平变化能提前预知胰岛素抵抗,从而间接对糖尿病筛查提供重要依据。
Objective： To investigate the clinical significance of changes of serum 1,5 in patients with pre diabetes at 101 level. Methods： a total of 153 cases were randomly selected from June -2016, January 2016 in our hospital, the endocrine clinic, the hospi- tal and the medical center. Impaired fasting glucose group （IFG） 40 cases, impaired glucose tolerance group （IGT） 43 eases, 35 cases of IGT IFG＋ group, 35 cases of healthy control group （NC）. They observe the fasting blood glucose （FPG）, glucose tolerance after 2 hours blood glucose （2hPG）, glycosylated hemoglobin （HbA1 c）, serum 5-AG 1 level, fasting insulin （FINS）, homeostasis model assessment of insulin resistance index HOMA-IR. Results： a total of 1 healthy controls, 5-AG levels were significantly higher than those in pre dia- betes groups, P〈0.05, have statistical significance; the control group were FPG, HbAlc and prediabetes had no significant difference, P〉0.05, no statistical significance in 1 groups; pre diabetes, 5-AG was negatively correlated with levels of FPG, HbAlc, HOMA-IR （P〈0.001） FPG, and HbAlc was positively correlated with HOMA-IR （P〈0.05）. Conclusion： the change of 1,5-AG level can predict insulin resistance in advance, so as to provide an important basis for diabetes screening.
作者
黄彩艳
谢冠聪
张正生
Huang Caiyan et al(Shenzhen City Pingshan New District People ＇s Hospital（Guangdong province518118)
出处
《黑龙江医药》
CAS
2017年第2期281-283,共3页
Heilongjiang Medicine journal
