摘要
目的探讨新辅助化疗结合保肢手术治疗骨肉瘤的临床效果。方法选取2012年5月~2014年4月在广西中医药大学第一附属医院住院的实施保肢手术的26例四肢骨肉瘤患者,并分别于术前、术后进行辅助化疗。患者出院后加强随访,并对恢复情况进行功能评定。结果随访期内根据患者术后功能评定优11例(42.31%)、良7例(26.92%),优良率为69.23%(18/26),总有效率为88.46%。根据生存曲线图得出:患者治疗后1年无瘤生存率为92.3%(24/26);治疗后2年无瘤生存率为74.1%(19/26);治疗后3年无瘤生存率为50.0%(13/26)。结论新辅助化疗结合保肢手术治疗骨肉瘤患者效果较好,值得临床推广应用。
Objective To explore the clinical efficacy of neoadjuvant chemotherapy combined with limb salvage surgery in the treatment of osteosarcoma. Methods From May 2012 to April 2014, 26 patients with limb osteosarcoma with limb salvage surgery in the First Affiliated Hospital of Guangxi University of Chinese Medicine were selected, and they were treated with preoperative and postoperative adjuvant chemotherapy. All the patients were followed up after discharge, and functional assessment of recovery was performed. Results During the follow-up period, 11 cases （42.31%） were evaluated to be excellent, while 7 cases （26.92%） were good according to the patient postoperative function, the excel- lent and good rate was 69.23% （18/26）, the total effective rate was 88.46%. According to the survival curve, the 1,2,3 year disease-free survival rate after treatment were 92.3% （24/26）, 74.1% （19/26） and 50.0% （13/26）. Conclusion Neoadjuvant chemotherapy combined with limb salvage surgery is good for patients with osteosarcoma, which is worthy of clini- cal application.
作者
杜敏东
易生辉
秦刚
何凯毅
黄肖华
曾平
陈劲
DU Mindong YI Shenghui QIN Gang HE Kaiyi HUANG Xiaohua ZENG Ping CHEN Jin(The Third Department of Orthopedic, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530023, China The Second Department of Orthopedic, Yueyang Chinese Medicine Hospital, HuMan Province, Yueyang 414000, China)
出处
《中国医药导报》
CAS
2017年第29期7-10,共4页
China Medical Herald
基金
国家自然科学基金项目(81360550)
广西自然科学基金项目(2014GXNSFAA118250)
关键词
骨肉瘤
新辅助化疗
保肢手术
Osteosarcoma
Neoadjuvant chemotherapy
Limb-salvage surgery
