摘要
目的研究新疆维吾尔族宫颈糜烂女性阴道菌群及局部免疫状况。方法选取60例维吾尔族宫颈糜烂患者和60例正常维吾尔女性,无菌棉签拭子留取宫颈分泌物进行清洁度鉴定并进行细菌培养,ELISA检测阴道冲洗液上清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)。结果维吾尔族宫颈糜烂等级轻的患者阴道分泌物患有细菌量较多,以革兰氏阳性杆菌和革兰氏阳性球菌为主。维吾尔族宫颈糜烂等级严重患者阴道清洁度以Ⅲ-Ⅳ为主,阴道分泌物乳酸杆菌、棒状杆菌、加德纳菌检出率与正常对照组存在明显差异,阴道局部IL-1β、IL-6、TNF-α、IL-8水平增高。结论阴道菌群和局部炎症因子共同参与了维吾尔族女性宫颈糜烂的发生。
Objective To investigate the vagina flora constitute and local immune status of vagina.Methods 60 Uyghur cervical erosion patients and 60 Uyghur health women were enrolled in the study.Cervical secretions were used for vaginal cleanliness detection and bacteria culture.Supernatant of vagina flush fluid were used for detection of IL-1β,IL-6,TNF-αand IL-8.Results In patients with mild cervical erosion,there were more bacteria in bacterial species and quantity in vaginal fluid,mainly gram positive bacilli and gram positive cocci.Vaginal cleanliness of patients with severe cervical erosion were mainly Ⅲ-Ⅳdegree.There were significant difference of positive rate of lactobacillus,corynebacterium,and gardiner between women with cervical erosion and health control.The levels of IL-1β,IL-6,TNF-α,IL-8 in vagina were found to be higher than that of health control.Conclusion Vagina flora and vaginal inflammatory factor may be involved in the progress of Uyghur cervical erosion.
出处
《新疆医科大学学报》
CAS
2017年第10期1269-1272,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金(81660475)
关键词
维吾尔族
宫颈糜烂
阴道菌群
炎症介质
Uyghur
cervical erosion
vagina flora
mediators of inflammation
