摘要
目的比较氨磺必利与喹硫平对男性精神分裂症患者甲状腺激素和性激素水平的影响。方法 62例精神分裂症患者随机分为治疗组和对照组,每组31例,分别给予氨磺必利系统治疗与喹硫平系统治疗,共12周。于治疗前和治疗12周末检测两组患者血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、催乳激素(PRL)、血清促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(Ts)水平。结果治疗12周末,研究组、对照组的TT3、TT4、FT4水平较同组治疗前低(P<0.05),对照组的TSH水平较同组治疗前高(P<0.05);研究组的TT4水平较同期的对照组高(P<0.05);研究组PRL、E2水平较同组治疗前明显增高,且高于同期的对照组(P<0.05)。结论氨磺必利和喹硫平都能降低男性精神分裂症患者甲状腺激素水平,喹硫平对T4影响较大,而氨磺必利对性激素影响大于喹硫平。
Objective To compare the effect of amisulpride and quetiapine on the thyroid hormone and sex hormone level of male schizophrenic patients. Methods 62 patients with schizophrenia were randomly divided into Treatment Group and Control Group, 31 cases in each group. The two groups were treated with amisulpride system and quetiapine system for a total of 12 weeks, respectively. The total triiodothyronine （TT3）, total thyroxine （TT4）, thyroid stimulating hormone （TSH）, free triiodothyronine （FT3）, free thyroxine （FT4）, prolactin （PRL）, follicle stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）, progesterone （P） and testosterone （Ts） level of the two groups were detected before treatment and after 12 weeks of treatment. Results After 12 weeks of treatment, the TT3, TT4 and FT4 levels of the Treatment Gropu and Control Group were significantly lower than those before treatment （P〈0.05）, and the TSH level in Control Group was higher than that before the treatment （P〈0.05）; The TT4 level of Treatment Group was higher than that of Control Group at the same period （P〈0.05）; The PRL and E2 levels of the Treatment Group were significantly higher than those before the treatment, and higher than those of Control Group at the same period （P〈0.05）. Conclusion Amisulpride and quetiapine can reduce the thyroid hormone level in male patients with schizophrenia. Quetiapine has a greater influence on T4 while amisulpride has a greater influence on sex hormone.
出处
《广东医科大学学报》
2017年第1期65-67,共3页
Journal of Guangdong Medical University
