摘要
慢加急性乙型肝炎肝衰竭(Hepatitis B-induced acute on chronic liver failure,HB-ACLF)主要由免疫介导损伤引起的肝功能损伤。越来越多的研究发现,调节性T细胞(Regulatory T cell,Treg细胞)和辅助性T细胞17(T helper cell 17,Th17)在HB-ACLF的免疫发病机制中发挥重要作用。Treg和Th17细胞起源于相同初始CD4+T细胞,但在分化及功能上相互制约。研究表明Treg细胞、Th17细胞及Treg/Th17比值失衡与HB-ACLF发生进展密切相关。
Hepatitis B-induced acute on chronic liver failure （HB-ACLF） is mainly due to the immune-mediated liver injury. More and more studies have found that regulatory T （Treg） ceils and T helper cell 17 （Thl7） play important roles in the immunopathogenesis of HB-ACLF. Treg and Th17 originate from the same initial CD4＋T cells,but restrict each other in differentiation and functions. Studies have indicated that the imbalance of Treg/Th17 ratio is closely related to the occurrence and development of ACLF. This article reviews the role of Treg/Thl7 in the pathogenesis of ACLF,and provides materials in the study of immunological field of liver failure.
出处
《实用肝脏病杂志》
CAS
2017年第5期639-642,共4页
Journal of Practical Hepatology
