摘要
衰弱是老年人因生理储备下降而出现抗应激能力减退的状态或综合征，是老年人常见的健康问题。衰弱增加了老年人发生失能、跌倒、谵妄、甚至死亡等不良事件的风险。然而，目前治疗衰弱的方法和效果有限，需要根据衰弱的发病机制和病理生理变化找出新的靶点。小鼠在生理上与人类相似，是人类疾病理想的动物模型。建立小鼠模型可在控制基因和环境因素的前提下，深入研究衰弱的发病机制，为进一步防治衰弱奠定基础。目前关于衰弱小鼠模型的研究尚处于起步阶段，仍需要进一步研究。本文对此进行综述，为未来相关动物模型研究提供新的思路。
Frailty is a common state or syndrome with a decline in physiological reserves and an increase in an individual＇s vulnerability for stress in the elderly. Frailty can increase the risk of disability, falls, hospitalization, delirium and mortality. However, the intervention of frailty is under the scarcity and its effectiveness is not satisfied. We need to find new targets to treat frailty according to the pathophysiology of frailty. Human physiology is very similar to that of mouse, thus, mouse can be an ideal animal model of human disease. Mouse models can provide insight into pathogenesis of frailty by reducing the influence of genetic and environment factors and provide more basic data for further studies of frailty. At present, the research on a mouse model of frailty is still in its infancy and still needs further study. This review will summarize the related studies and propose some new ideas for future studies on mouse model of frailty.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2017年第9期1041-1043,共3页
Chinese Journal of Geriatrics
基金
国家自然科学基金（81601220）
四川省科技厅（2017RZ0040）
关键词
衰弱
模型
动物
Frailty
Models, animal
