摘要
目的:了解我院新的、严重的药品不良反应(ADR)发生的特点和临床表现,为预防ADR发生和临床合理用药提供参考。方法:采用回顾性方法,对我院2007~2016年收集的277例新的、严重的ADR报告,从患者的年龄、性别分布、给药途径、药物类别与品种数、累及的系统/器官及临床表现、不良反应分型等进行统计和分析。结果:277例患者中,50~69岁患者所构成比例最大(42例,45.13%);新的ADR 99例,严重的ADR(包括新的严重ADR)178例;注射剂178例(64.26%),口服85例(30.69%);新的严重的ADR涉及药品种类以抗感染药(26种,19.12%)、抗肿瘤药(25种,18.38%)和中药制剂(19种,13.97%)最多。严重不良反应的临床表现以消化系统、皮肤及其附件和血液系统的损害最多;新的不良反应的临床表现以消化系统、皮肤及其附件和循环系统的损害最为多见。结论:应重视和加强新的ADR的监测和上报,合理用药,保障患者用药安全。
Objective： To investigate the characteristics and regulars of the new and serious adverse drug reactions in order to provide a reference for prevention of the ADR and rational administration of the drugs. Methods： A total of 277 the new and serious ADR case reports from 2007 to 2016 were collected in our hospital. Age distribution,gender,route of administration,drugs categories,systems and organs involved and clinical manifestations,adverse reaction types. Results：Of the 277 cases,patients aged 50-69 years took the highest proportion with 42 cases（ 45. 13%）; there were 99 new ADRs and 178 serious ADRs（ including new and serious cases）. From the perspective of route of administration,injection（ 178 cases,64. 26%） and oral preparations（ 85 cases,30. 69%） more likely caused the new and serious ADR. From the perspective of drug types,most of the new and serious ADRs were induced by anti-infection drugs（ 26 cases,19. 12%）,anticancer drugs（ 25 cases,18. 38%） and Chinese patent drugs（ 19 cases,13. 97%）. The clinical manifestations of severe adverse reactions were most common in digestive system,skin and appendix,hematological system damages. The clinical manifestations of new adverse reactions were most common in digestive system,skin and appendix,circulatory system damages. Conclusion： We should pay attention to and strengthen monitoing and reporting on new or serious ADR and rational use of drugs in order to ensure patients＇ medication safety.
作者
朱春梅
吴民
Zhu Chunmei Wu Min(Central Hospital of Karamay City, Keramay 834000, Xinjiang, Chin)
出处
《药物流行病学杂志》
CAS
2017年第8期551-555,共5页
Chinese Journal of Pharmacoepidemiology
