摘要
目的探讨非负压抽吸联合单纯α-糜蛋白酶单纯液化引流对颅内血肿的临床效果。方法选取我院2014年1月~2016年1月收治的行微创清除引流术治疗的85例颅内血肿患者作为研究对象,根据治疗方法的不同将其分为对照组(33例)与治疗组(52例),对照组方法为采取2 ml负压抽吸,应用粉碎器冲洗,并予以α-糜蛋白酶液化抽吸引流;治疗组方法为非负压抽吸联合单纯α-糜蛋白酶单纯液化引流。比较两组的治疗效果。结果两组的水肿程度、血肿清除率比较,差异无统计学意义(P>0.05);治疗组的并发症发生率、死亡率低于对照组,差异有统计学意义(P<0.05)。结论非负压抽吸联合单纯α-糜蛋白酶单纯液化引流应用在颅内血肿中可减少对患者脑组织的二次损伤,降低死亡率、并发症发生率,改善患者的预后,具有推广价值。
Objective To investigate the clinical effect of non negative pressure aspiration combined with simple α-chymotrypsin for simple liquefaction drainage on intracranial hematoma.Methods Fifty-five patients with intracranial hematoma treated with minimally invasive drainage were selected from January 2014 to January 2016 as objects.They were divided into control group（33 cases） and treatment group（52 cases） according to different treatment methods.The control group method was given 2 ml negative pressure aspiration,pulverizer was used toflush,and was given α-chymotrypsin liquefaction suction drainage,while treatment group method was given non-negative pressure aspiration combined with simple α-chymotrypsin liquefaction drainage.Tratment effect between the two groups was compared.Results There was no significant difference between the two groups in the degree of edema and the rate of hematoma removal（P〉0.05）.The incidence rate of complications and mortality in treatment group were significantly lower than those in the control group（P〈0.05）.Conclusion Non negative pressure aspiration combined with simple α-chymotrypsin for simple liquefaction drainage treating intracranial hematoma can reduce the secondary damage to the brain tissue,reduce mortality and incidence rate of complications,and improve the prognosis of patients.It has a promotion value.
作者
蒋新作
肖媛媛
黄晨敏
张军
JIANG Xin-zuo XIAO Yuan-yuan HUANG Chen-min ZHANG Jun(Department of the Second Cerebrovascular Disease,the Second People＇s Hospital of Shaoyang City in Hunan Province, Shaoyang 422000,Chin)
出处
《中国当代医药》
2017年第22期36-38,44,共4页
China Modern Medicine
基金
湖南省卫生计生委科研计划课题(B2016187)
关键词
Α-糜蛋白酶
微创清除引流术
粉碎冲洗
抽吸
液化引流
血肿
生化酶
α-chymotrypsin
Minimally invasive removal and drainage
Crush and rinse
Aspiration
Liquefaction drainage
Hematoma
Biochemical enzyme
