摘要
目的:观察并分析通心络联合瑞舒伐他汀钙片、拜阿司匹林对高脂血症伴颈动脉粥样硬化的治疗效果。方法:选择门诊治疗伴有颈动脉粥样硬化的高脂血症患者64例,采用随机数字表法将患者分为2组,对照组32例患者给予瑞舒伐他汀钙片联合拜阿司匹林治疗,治疗组32例患者给予"金三角"方案(通心络联合瑞舒伐他汀钙片、拜阿司匹林)联合治疗。测定患者晨起空腹血脂及血浆同型半胱氨酸(Hcy)、高敏C-反应蛋白(hs-CRP)水平,并采用颈动脉彩色多普勒超声检测患者颈动脉内-中膜厚度(c IMT)及斑块数量、面积。治疗6个月后,对2组患者治疗前后的血脂、血浆Hcy、hs-CRP水平及颈动脉粥样硬化斑块治疗情况进行分析比较。结果:2组患者经治疗后空腹血浆三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、Hcy、hs-CRP水平及颈动脉斑块数量、面积、c IMT等均较治疗前有明显改善,且治疗组效果优于对照组(P<0.05,P<0.01)。结论:"金三角"方案对伴有颈动脉粥样硬化的高脂血症患者血脂、血浆Hcy、hs-CRP水平及颈动脉斑块情况均有明显的改善作用,其效果优于单纯应用西药治疗。
Objective：To investigate the effect of Tongxinluo（TXL）, rosuvastatin calcium tablets and bayaspirin in treatment of hyperlipidemia associated with carotid atherosclerosis.Methods：Sixty-four cases of hyperlipidemia associated with carotid atherosclerosis were divided into a control group （32 cases） and a treatment group （32 cases） by random number table method.The control group was treated with rosuvastatin calcium tablets and bayaspirin, the treatment group “Golden Triangle” program （TXL, rosuvastatin and rosuvastatin calcium tablets and bayaspirin）, and the course was 6 months.The blood lipid levels, homocysteine （Hcy）, high sensitive C-reactive protein （hs-CRP） level and carotid artery intima-media thickness （cIMT）, number and area of plaques of patients in the two groups before and after treatment were detected.And those data were compared again after 6 months.Results：After treatment, the blood lipid levels, Hcy, hs-CRP levels and cIMT, and number and area of plaques were significantly improved comparing with before, and the effect of the treatment group was better than the control group（P〈0.05,P〈0.01）.Conclusion：The treatment effect of “Golden Triangle” program of carotid atherosclerosis were better than the simple combination of rosuvastatin calcium tablets and bayaspirin.
出处
《世界中医药》
CAS
2017年第4期807-810,共4页
World Chinese Medicine
基金
河北省中医药管理局资助项目(编号:2014082)
