摘要
目的通过动态检测糖尿病患者尿路感染治疗前后血清视黄醇结合蛋白(RBP)和白细胞(WBC)变化,为预防和治疗提供参考依据。方法回顾性收集江苏省人民医院确诊为尿路感染患者的资料,从中筛选出93例资料完整的病例,其中48例为血糖正常患者(A组),45例为糖尿病患者(B组),记录患者病程中的RBP和WBC结果,同时以50例健康体检者作为对照组(C组)。结果 A组和B组患者入院时RBP和WBC水平明显高于C组[RBP(mg/L):31.78±11.88、36.16±12.42比30.56±10.20,WBC(×10~9/L):7.01±3.19、6.82±2.58比6.45±2.60],发生尿路感染时升高更加明显[RBP(mg/L):34.54±11.71比31.78,48.46±14.67比36.16±12.42;WBC(×10~9/L):8.94±4.66比7.01±3.19,10.93±5.14比6.82±2.58;均P<0.05];而治愈出院时两组值都已降至入院时。在两组尿路感染患者中,伴糖尿病的B组各时间点RBP和WBC值均高于不伴糖尿病的A组,且发生尿路感染时两值都出现统计学意义(均P<0.05)。相关性分析显示,A组患者尿路感染时的RBP和WBC升高比例相关性很小,相关系数r=0.181,P>0.05,B组患者尿路感染的RBP和WBC升高比例成显著的正相关,相关系数r=0.484,P<0.05。结论糖尿病患者比非糖尿病患者尿路感染时的RBP和WBC升高幅度要大,血清RBP检测可作为糖尿病尿路感染患者监测病情、评估预后的一种方法,非糖尿病尿路感染患者RBP升高不是很明显,若有显著升高应警惕其他疾病的发生。
Objective To provide reference for the prevention and treatment of diabetics with urinary tract infection through dynamically detecting the variation of retinol binding protein （RBP） and white blood count （WBC） before and after treatment. Methods 93 complete cases were selected from the data of patients diagnosed as urinary tract infection by retrospectively gathering the patient files in Jiangsu Province Hospital, including 48 cases with normal blood glucose level （group A） and 45 cases of diabetics （group B）; the RBP and WBC results of these patients during course of the disease were collected, and meanwhile, 50 cases with healthy physical examination were selected as the control group （group C）. Results The RBP and WBC of patients in group A and Group B when being hospitalized was relatively higher than that of Group C, with the RBP level （mg/L） of 31.78 ± 11.88, 36.16 ± 12.42, and 30.56 ± 10.20, respectively, while the WBC （X 109/L） level of Group A, B and C to be 7.01 ± 3.19, 6.82±2.58 and 6.45±2.60, respectively. When the urinary tract infection occurred, the corresponding RBP （mg/L） level of Group A-C was even higher, to be 34.54± 11.71, 31.78± 11.88, 48.46± 14.67, and 36.16±_ 12.42, respectively, while the WBC （X 109/L） to be 8.94±4.66, 7.01 ± 3.19, 10.93 ± 5.14, and 6.82± 2.58, respectively, with the average error P 〈 0.05. Both the RBP and WBC level decreased to the same level as that of the time admitted to hospital. As for the two groups of patients with urinary tract infection, the RBP and WBC level of Group B with diabetes was higher at all timing point than that of Group A without diabetes, and also the change of both levels had statistical significance when got effected via urinary infection, with the average error P 〈 0.05. The correlation analysis showed that the correlation index was small for the relationship of RBP and WBC increase in Group A when got urinary infection, with the index r = 0.181 and P 〉 0.05. Meanwhile, the increase of RBP and WBC level ofGroup B was obviously correlated with each other when getting urinary infection, with the correlation index r = 0.484 and P 〈 0.05, respectively. Conclusions Comparing with patients without diabetes, the diabetic patients would have higher increase of RBP and WBC level when got urinary infection. The RBP measurement in serum could be used as a method to monitor the illness state and evaluate prognostic situation of diabetic patients with urinary infection. The RBP level of non-diabetic patients would not have a great increase even with urinary infection. If the RBP level greatly increased, we have to be aware of the occurrence of some other diseases.
出处
《实用检验医师杂志》
2017年第2期86-88,共3页
Chinese Journal of Clinical Pathologist
关键词
糖尿病
尿路感染
视黄醇结合蛋白
白细胞
Diabetes
Urinary tract infection
Retinol binding protein
White blood count
