摘要
目的探讨生长抑素联合肠外营养支持在大肠癌合并肠梗阻患者保守治疗中的应用效果。方法选择66例大肠癌合并肠梗阻患者,按照随机数字法分为实验组与对照组各33例。对照组予以肠外营养支持、胃肠减压、纠正水电解质失衡的常规治疗方法,实验组则在对照组的基础上采取静脉滴注生长抑素治疗。比较2组患者肠梗阻临床指标改善情况、血液指标、代谢紊乱发生情况、临床疗效。结果实验组腹痛腹胀缓解率、肛门排气排便缓解率显著高于对照组,腹痛腹胀、肛门排气排便消失时间或恢复时间显著短于对照组,胃肠减压引流量显著低于对照组(P<0.05)。治疗后,实验组白蛋白、前白蛋白、CRP、TNF-α、血红蛋白、WBC等血液指标均显著优于对照组(P<0.05)。治疗后,实验组血糖异常、血钾异常及血钠异常发生率显著低于对照组(P<0.05)。治疗后实验组有效率为81.82%,显著高于对照组57.58%(P<0.05)。结论生长抑素联合肠外营养支持应用于大肠癌合并肠梗阻患者保守治疗中可有效改善患者临床症状,减少胃肠减压引流量,改善血液指标、代谢紊乱,提高有效率。
Objective To explore the application of somatostatin combined with parenteral nutrition in the treatment of patients with colorectal cancer complicated with intestinal obstruction.Methods A total of 66 patients with colorectal cancer complicated with intestinal obstruction were randomly divided into experimental group and control group,33 cases in each group. The control group was treated with parenteral nutrition,gastrointestinal decompression,conventional treatment for water electrolyte imbalance,while experimental group was treated with intravenous infusion of somatostatin on the basis of the control group. Clinical indicators,blood indexes,metabolic disorders,clinical curative effect were compared between two groups. Results In the experimental group,abdominal pain remission rate and anal exhaust defecation remission rate were significantly higher than the control group,abdominal pain,anal exhaust defecation or disappearance time recovery time were significantly less than the control group,and gastrointestinal decompression drainage was significantly lower than the control group（ P〈0. 05）. After treatment,the blood indexes such as albumin,pre albumin,CRP,TNF-α,hemoglobin,WBC in experimental group were significantly better than those in the control group（ P〈0. 05）. In the experimental group,blood glucose abnormalities,abnormal blood glucose and abnormal rate of blood sodium were significantly lower than the control group（ P〈0. 05）. After treatment,the effective rate of the experimental group was 81. 82%,which was significantly higher than 57. 58% of the control group（ P〈0. 05）. Conclusion Somatostatin combined with parenteral nutrition can effectively improve clinical symptoms in patients with colorectal cancer complicated with intestinal obstruction,reduce gastrointestinal decompression drainage,improve blood indexes and metabolic disorders,and increase effective rate.
出处
《实用临床医药杂志》
CAS
2017年第13期64-66,71,共4页
Journal of Clinical Medicine in Practice
基金
湖北省自然科学基金(kb2017222)
关键词
生长抑素
肠外营养
大肠癌
肠梗阻
somatostatin
parenteral nutrition
colorectal cancer
intestinal obstruction
