摘要
目的:探讨益气温阳中药治疗膝骨关节炎疗效及对炎性细胞因子、NO水平的影响。方法:选取2013年1月至2016年6月收治的膝骨关节炎患者共100例,随机分为对照组(50例)和中西医结合组(50例),分别给予西药单用和在此基础上加用益气温阳中药辅助治疗,比较两组患者临床疗效、治疗前后中医证候积分、WOMAC评分、TNF-α、IL-1β、IL-6及NO水平等。结果:中西医结合组患者临床疗效显著优于对照组(P<0.05);中西医结合组患者治疗后中医证候积分和WOMAC评分均显著低于对照组、治疗前(P<0.05);中西医结合组患者治疗后TNF-α、IL-1β及IL-6水平均显著低于对照组、治疗前(P<0.05);中西医结合组患儿治疗后NO水平显著低于对照组、治疗前(P<0.05)。结论:益气温阳中药治疗膝骨关节炎可有效缓解减轻症状体征,改善关节功能,抑制炎症反应程度,并有助于下调NO水平。
Objective:To investigate the effects of Yiqi Wenyang herbs on the treatment of knee osteoarthritis and on inflammatory cytokines and NO levels.Methods:100patients with knee osteoarthritis from January 2013to June 2016had been randomly divided into the control group(50cases)and the study group(50cases)in which traditional Chinese medicine and Western treatment had been integrated.In the control group only glucosamine sulfate had been applied,glucosamine sulfate plus Yiqi Wenyang herbs in the study group.Clinical curative effects had been observed,traditional Chinese medicine(TCM)symptom scores and the Western Ontario and McMaster Universities(WOMAC)osteoarthritis indexes had been tested before and after treatment,and some fluid factors such as TNF-alpha,IL-1beta,IL-6and NO levels had been measured.Results:The clinical curative effects were significantly better in the study group than the control group(P<0.05);TCM syndrome scores and WOMAC osteoarthritis indexes were significantly lower than in the control group or before treatment(P<0.05);TNF-alpha,IL-1beta and IL-6were more significantly decreased(P<0.05);and NO levels also more decreased than the control group or before treatment(P<0.05).Conclusion:Yiqi Wenyang herbs can effectively relieve symptoms and signs,improve joint function of the patients with knee osteoarthritis,inhibit inflammatory reactions,and help reduce NO levels.
出处
《长江大学学报（自然科学版）》
CAS
2017年第12期1-3,共3页
Journal of Yangtze University(Natural Science Edition)
基金
湖北省教育厅科研计划项目(D20121204)
关键词
中医药
膝骨关节炎
炎性细胞因子
NO
Chinese herbs
knee osteoarthritis
inflammatory cytokines
NO levels
