摘要
目的探讨不同质量浓度舒芬太尼复合罗哌卡因对分娩孕妇镇痛效果和子宫收缩的影响。方法选取2015年8月~2016年3月在我院待产的行硬膜外分娩镇痛的128例产妇,随机分为对照组、低剂量组、中剂量组、高剂量组,每组32例。对照组给予单纯0.1%罗哌卡因,低剂量组给予0.2μg/ml舒芬太尼复合0.1%罗哌卡因,中剂量组给予0.4μg/ml舒芬太尼复合0.1%罗哌卡因,高剂量组给予0.6μg/ml舒芬太尼复合0.1%罗哌卡因。比较四组给药前后的VAS评分、产程时间、新生儿Apgar评分及不良反应发生率。结果四组产妇给药前的VAS评分比较,差异无统计学意义(P>0.05);给药后10 min、宫口开全、胎儿娩出后,随着舒芬太尼给药剂量的增大,VAS评分下降明显,均较对照组低(P<0.05);低、中、高剂量组产妇的第一产程时间均较对照组短,其中低剂量组与中剂量组的第一产程时间较高剂量组低(P<0.05);四组的第二产程时间、第三产程时间及新生儿Apgar评分比较,差异无统计学意义(P>0.05);高剂量组的不良反应发生率较低、中剂量组较高(P<0.05)。结论对于行硬膜外分娩镇痛的产妇,舒芬太尼0.4μg/ml复合0.1%罗哌卡因镇痛效果好,安全性高,可明显缩短第一产程,值得临床推广。
Objective To explore the influence of Sufentanil combining with Ropivacaine in different concentrations on analgesia and uterine contraction in pregnant women.Methods 128 pregnant women who would given birth in our hospital from August 2015 to March 2016 undergone epidural analgesia were selected and randomly divided into the control group,the low dose group,the medium dose group,the high dose group,32 cases in each group.The control group was given 0.1% Ropivacaine alone,the low dose group was given 0.2 μg/ml Sufentanil combining with 0.1% Ropivacaine,the medium dose group was given 0.4 μg/ml Sufentanil with 0.1% Ropivacaine,the high dose group was given 0.6 μg/ml Sufentanil with 0.1% Ropivacaine.The VAS score,the time of labor,the Apgar score of newborns and the incidence rate of adverse reactions were comprehensively compared among the four groups before and after administration.Results There was no significant difference in the VAS score among the four groups before administration（P〉0.05）.10 minutes after administration,total opening of uterine neck,anddelivery of baby,with the increase of Sufentanil dose,the VAS scores were greatly decreased,which were all lower than that in the control group（P〈0.05）.The first stage of labor in the low,middle and high dose group was shorter than that in the control group,among them,the first stage of labor in the low and middle dose group were both shorter in comparison with that in the high dose group（P〈0.05）.There was no significant difference in the second stage of labor,the third stage of labor,and Apgar scores of newborns among four groups（P〉0.05）.The incidence rate of adverse reaction in the high dose group was lower and higher in the middle dose group（P〈0.05）.Conclusion For pregnant women undergone epidural analgesia,0.4 μg/ml Sufentanil with 0.1% Ropivacaine obtains great analgesic effect in high safety.It can greatly shorten the first stage of labor and is worthy of clinical promotion.
出处
《中国当代医药》
2017年第17期108-110,共3页
China Modern Medicine
基金
广东省佛山市自筹经费类科技计划项目(2016AB000622)
