乙型肝炎病毒相关肝病患者RPR的变化及意义被引量：5

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摘要目的观察乙型肝炎病毒(HBV)相关肝病患者外周血红细胞分布宽度(RDW)与血小板计数的比值(RPR)变化,并探讨其临床意义。方法收集2013年3月至2016年3月本院就诊的慢性HBV感染患者174例,观察不同病情患者RPR值差异,并分析其与临床常用实验室指标相关性,用受试者工作特征曲线(ROC)及曲线下面积(AUC)判断RPR对肝硬化的预测价值。结果乙型肝炎肝硬化、慢性乙型肝炎患者的RPR均明显高于健康对照组,3组之间比较差异有统计学意义(P<0.05);慢性HBV感染者RPR与总胆红素(TBil)呈正相关(r=0.459,P<0.05),与白蛋白(Alb)、白细胞(WBC)、血红蛋白(Hb)呈负相关,相关系数r分别为-0.515、-0.627、-0.435(P<0.05);ROC分析显示,RPR诊断乙型肝炎肝硬化的AUC为0.881,与FIB-4(0.86)相似(P>0.05),显著高于AAR(0.731)、APRI(0.712),差异有统计学意义(P<0.05)。结论 RPR水平有助于HBV相关肝病病情严重程度的判断。

作者赵丽连敏陈胜良马雄

机构地区上海交通大学医学院附属仁济医院南院消化内科上海市消化疾病研究所上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所

出处《肝脏》 2017年第6期526-528,共3页 Chinese Hepatology

基金国家自然青年科学基金项目(81300300) 上海高校青年教师培养资助计划(jdy11059)

关键词乙型肝炎肝硬化 RPR

分类号 R512.62 [医药卫生—内科学]

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参考文献3

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