摘要
目的探析红细胞输血无效与低效价不规则抗体漏检的相关性。方法选择2014年6月~2015年4月临床输血患者1 987例,发现无效红细胞输血者196例,应用LISS/Coombs卡重新检测输血前样本,分析是否存在低效价不规则抗体情况。统计分析低效价不规则抗体与妊娠次数、输血次数、年龄、性别、输血不良反应等因素的关系。结果 1 987例临床输血病例出现红细胞输血无效196例(9.9%),其中因低效价不规则抗体漏检引起输注无效30例(15.3%)。极易出现红细胞输血无效为妊娠次数≥3次(χ~2=4.32,P=0.04)、输血次数≥3次(χ~2=6.43,P=0.01)、男性(χ~2=9.32,P<0.01)、年龄>60岁(χ~2=6.74,P=0.01)及出现输血不良反应(尤其是迟发性输血反应)者。结论低效价不规则抗体是输血无效的原因之一,与妊娠次数、妊娠史、输血次数、性别、年龄、输血不良反应等因素有关。
Objective Clinical observation and exploration of the relevance of the invalid red blood cells （RBCs） transfusion and the undetectable low titer and irregular antibodies. Methods One hundred and ninety-six patients with invalid RBCs transfusion were selected from 1 987 clinical cases frim Jun 2014 to April 2015. The ratio of low titer irregular antibodies in pre-transfusion samples was retested using LISS/Coombs cards. Simultaneously, the relationship between the lower titer irregular antibodies and pregnancy, volume of blood transfusion, ages, gender, adverse effect of transfusion, etc. Results The percentage of invalid RBCs transfusion in the 1987 cases oftransfusionwas 9.9%, , among them, 30 cases of undeteetable low titer irregular antibodies were screened out. The ineffective RBCs transfusion and low titer irregular antibodies were closely related with the number of pregnancy （X2=4.32, P=0.04） , volume of blood transfusions （x2=6.43, P=0.01） , ages （x2=6.74, P=0.01） , gender （x2=9.32, P〈0.01） , and adverse reactions of blood transfusion （x2=4.33, P= 0.04） . Conclusion The low titer irregular antibodies is one of the reasons for invalid red blood transfusion, and closely related with the number of pregnancy, ages, gender, volume and adverse reactions of blood transfusion
出处
《临床输血与检验》
CAS
2017年第3期243-245,共3页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
红细胞输血无效
不规则抗体
低效价
Invalid red blood cells transfusion Irregular antibodies Low titer
