摘要
目的:探讨心肌缺血后处理的有效介入时间窗。方法:计算机检索中国期刊全文数据库(CNKI)、万方数据库、中文科技期刊数据库(VIP)、中国生物医学文摘数据库(CBM)和Pubmed,收集关于后处理抗心肌缺血再灌注损伤的现代文献,对符合纳入标准的文献从发表年份、研究对象、样本量、干预措施、结局指标、实验结果等方面进行统计分析。结果:最终纳入19篇文献,中文16篇,英文4篇,临床类研究2篇,动物类研究17篇。动物实验中,干预措施基本以西药缺血后处理(占47%)、典型后处理(占29%)为主。典型后处理的有效介入时间窗,从再灌注早期数分钟内延长到再灌注开启45min时介入仍能起到心脏保护的作用;西药缺血后处理的有效时间窗与介入治疗的药物相关。临床实验研究甚少,目前的干预措施为西药治疗。结论:后处理抗心肌缺血再灌注损伤的有效介入时间窗取决于介入的干预措施。后处理的研究从动物实验到临床研究的转化依旧存在着较大的问题,为推动其临床应用,需要更合理的研究方案,更大的样本量,更为标准的干预措施。
Objective:To explore the effective time window of ischemic postconditioning.Methods:A computer-based search of Chinese Journal Full-text Database(CNKI),Wanfang Database,Chinese Science and Technology Journals Database(VIP),Chinese Biomedical Abstract Database(CBM)and Pubmed was conducted to collect modern literature on postconditioning against myocardial ischemia-reperfusion injury,and the statistical analysis was made on the year of publication,the subjects,the sample size,the intervention measures,the outcome indexes and the experimental results in the literatures accorded with the inclusive criteria.Results:19articles were included,16 articles in Chinese,4 in English,2 in clinical studies and 17 in animal studies.In the animal experiment,the intervention measures were mainly western medicine post-ischemic postconditioning(47%)and typical post-processing(29%).The effective intervention time window of typical postconditioning could prolong the reperfusion time from a few minutes to the 45 minutes of reperfusion,and the intervention could still play a role in heart protection.The effective time window of western medicine after post-ischemic postconditioning was concerned with the drug of the interventional therapy.There were few clinical trials and the current intervention is Western medicine.Conclusion:The effective interventional time window for post-processing of myocardial ischemia-reperfusion injury depends on interventional interventions.There is still a big problem about post-processing research transformed from animal experiments to clinical studies.And more rational research programs,larger sample size and more standard interventions should be needed in order to promote its clinical application.
出处
《亚太传统医药》
2017年第11期28-32,共5页
Asia-Pacific Traditional Medicine
基金
国家自然科学基金(81573885)
关键词
心肌缺血再灌注
后处理
有效时间
Myocardial ischemia and reperfusion
Post-processing
Effective time
