摘要
肿瘤的转移是一种从局部病变到全身病变的演变过程,其中存在很多中间状态。寡转移属于肿瘤转移过程中的一种状态,是肿瘤生物侵袭过程中较温和的一个阶段。寡转移时转移灶数量有限,是一个介于局部原发灶和广泛远处转移之间的过渡阶段,但该阶段不具备向全身播散的倾向。寡转移的治疗主要以局部治疗为主。随着放疗技术与影像学技术的发展,放射治疗逐步成为一种重要的治疗手段;尤其是立体定向放射治疗技术已被证明是一种安全有效、不良反应小、能有效提高寡转移患者局部控制率及生存期的方法。尽管已取得良好的治疗效果,但立体定向放射治疗在对寡转移的控制中仍面临着各种挑战,尤其在患者的选择标准与治疗策略上。因此,本文就肿瘤寡转移以及放射治疗在寡转移治疗中的临床研究现状及进展进行综述,以期为寡转移患者提供一种更好的治疗方法。
Tumor metastasis is an evolution process from local lesion to systemic diseases, in which there are many intermediate states. Oligometastasis is a milder stage of tumor biological invasiveness, and also a state model in the process of tumor metastasis. With the limited less metastases, oligometastasis is a transitional stage between local primary tumor and extensive distant metastasis, and does not have the genetic tendency of systemic spread. Local therapy is mainly used for oligometastasis. Due to the development of radiation and imaging technology, the radiotherapy has gradually become an important treatment. Especially, the stereotactic radiotherapy has been proved to be safe and effective, with less adverse reactions, high local control rate and long-term survival. Despite of its good results and effects, the stereotactic radiotherapy is still facing various clinical challenges, especially in the selection criteria of candidate patients and therapeutic strategies. This paper reviews the clinical progress in tumor oligometastasis and the application of radiation therapy in the treatment of tumor oligometastasis, in order to provide a better treatment for the patients with oligometastasis.
出处
《肿瘤》
CAS
CSCD
北大核心
2017年第5期540-544,共5页
Tumor
基金
安徽省卫生厅"十二五"临床重点专科建设基金资助项目(编号:01Z33)~~
关键词
肿瘤
寡转移
放射疗法
Neoplasms
Oligometastases
Radiotherapy
