摘要
目的 对比分析光学药物压抑疗法与遮盖疗法对儿童斜视性或屈光参差性弱视的疗效.方法 前瞻性临床研究.收集2013年1月至2015年3月在我院诊断为斜视性或屈光参差性弱视的儿童患者,根据采用的弱视治疗方法不同分为遮盖疗法组（遮盖组）与光学药物压抑疗法组（压抑组）.根据弱视程度不同又分为轻度、中度、重度弱视进行分析.对随访12个月以上患者的弱视治疗效果进行分析比较.2组弱视程度比较采用Wilcoxon秩和检验,组间的有效率和治愈率比较采用χ^2检验.结果共纳入斜视性或屈光参差性弱视患者85例（85眼）,其中遮盖组52例（52眼）,压抑组33例（33眼）.遮盖组治愈率60%,压抑组治愈率64%,2组治愈率差异无统计学意义（χ^2=0.137,P=0.711）.遮盖组有效率88%,压抑组有效率85%,2组有效率差异无统计学意义（χ^2=0.234,P=0.629）.轻度、中度、重度弱视患者中,遮盖组与压抑组有效率差异均无统计学意义.遮盖组52只弱视眼均转为注视眼,压抑组进行药物压抑治疗3-6个月后,29只弱视眼转为注视眼,4只未转为注视眼,后改为遮盖疗法.结论 与传统遮盖疗法相比,光学药物压抑疗法对于儿童斜视性或屈光参差性弱视的治疗效果相近.
Objective To compare the effect of atropine drug penalization and patching therapies of children with anisometropic amblyopia or strabismus amblyopia. Methods In this prospective clinical study, children and adolescents diagnosed with anisometropic amblyopia or strabismus amblyopia who had complete clinical data of more than 12 months were recruited from January 2013 to March 2015. They were divided into an atropine penalization group and patching group. And patients were further divided into mild, moderate, severe degree to analyze. The degree of amblyopia for the two groups was compared with the Wilcoxon rank sum test. The effective rate and cure rate for the two groups were compared by chi-square tests. Results A total of 85 patients （85 eyes） with anisometropic or strabismus amblyopia were recruited and divided into a patching group of 52 patients （52 eyes） and an atropine penalization group of 33 patients （33 eyes）. The cure rates were 60% and 64% in the patching and penalization groups respectively （χ^2=0.137, P=0.711）. The effective rates were 88% and 85% for the patching and penalization groups respectively （χ^2=0.234, P=0.629）. There was also no significant difference between the two groups when the rates of effectiveness for different degrees of amblyopia were compared. Fifty-two eyes in the patching group and 29 eyes in the penalization group developed a fixating eye after 3-6 months of treatment, but 4 eyes in the penalization group did not develop a fixating eye. Conclusion Atropine drug penalization therapy has a similar effect on anisometropic or strabismus amblyopia in children as does traditional patching therapy.
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2017年第3期172-175,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
基金
山东省医药卫生科技发展计划项目（2015WS0334）
关键词
弱视
压抑疗法
遮盖疗法
屈光参差
斜视
儿童
Amblyopia
Penalization therapy
Patching therapy
Anisometropia
Strabismus
Children
