摘要
目的:观察黄芪生脉饮与复方丹参片联合常规疗法治疗早期2型糖尿病肾病的效果。方法:将87例早期2型糖尿病肾病气阴两虚兼血瘀型患者分为对照组42例和治疗组45例,2组均进行糖尿病教育、饮食控制、运动及常规降糖治疗,治疗组同时予以黄芪生脉饮联合复方丹参片治疗,疗程为12周,观察治疗前后2组患者的血糖、血小板参数、同型半胱氨酸(Hcy)、肾功能指标的变化。结果:治疗后,2组空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)均较治疗前下降(P<0.05);2组各指标比较,差异均无统计学意义(P>0.05)。2组平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)均较治疗前下降(P<0.01,P<0.05),治疗组MPV、PDW均低于对照组(P<0.05)。治疗组Hcy较治疗前下降(P<0.05),对照组无明显变化(P>0.05);治疗组Hcy低于对照组(P<0.05)。2组尿白蛋白排泄率(UAER)均较治疗前改善(P<0.01),治疗组UAER低于对照组(P<0.05);治疗组内生肌酐清除率(CCr)较治疗前亦有明显改善(P<0.05),而对照组CCr较治疗前无明显改善(P>0.05),治疗组CCr高于对照组(P<0.05)。结论:在西医常规疗法基础上加用黄芪生脉饮联合复方丹参片治疗早期2型糖尿病肾病气阴两虚兼血瘀型患者可保护肾脏的血管功能,改善微循环,起到良好的降低尿白蛋白、提高肾功能的作用,安全有效。
Objective：To observe the clinical effect of Huangqi Shengmai Yin combined with Compound Salvia tablets and routine treatment for early-stage type 2 diabetic nephropathy（DN）. Methods：Selected 87 patients with early-stage type 2 DN of Qi-Yin deficiency syndrome merged blood stasis syndrome,and divided them into the control group of 42 cases and the treatment group of 45 cases. The two groups were both given the therapy of diabetes education,alimentary control,exercise and the conventional hypoglycemic therapy,and the treatment group was given Huangqi Shengmai Yin combined with compound salvia tablets additionally. Treatment lasted for twelve weeks. Observed change of blood glucose,platelet parameter,homocysteine（Hcy） and indexes of renal function. Results：After treatment,fasting blood glucose（FBG）,postprandial 2 hours blood glucose（P2hBG）,glycosylated hemoglobin A1（HbA1c） of the two groups were lower than those before treatment（P〈0.05）. Compared every blood glucose index of the two groups, the difference had no significant（P〉0.05）. Mean platelet volumes（MPV）,thrombocytocrit（PCT） and platelet distribution width（PDW） of the two groups were lower than those before treatment（P〈0.01,P〈0.05）,and MPV and PDW of the treatment group were lower than those of the control group（P〈0.05）. Hcy levels of the treatment group were lower than those before treatment（P〈0.05）, and there was no significant change in the Hcy levels of the control group（P〉0.05）. Hcy levels of the treatment group were lower than those of the control group（P〈0.05）. Urinary albumin excretion rate（UAER） of the two groups was improved（P〈0.01）,and UAER of the treatment group was lower than that of the control group（P〈0.05）. Endogenous creatinine clearance（CCr） of the treatment group was improved（P〈0.05）,and there was no significant change in the CCr of the control group（P〈0.05）,CCr of the treatment group was higher than that of the control group（P〈0.05）. Conclusion：Huangqi Shengmai Yin combined with compound salvia tablets and routine treatment can protect vascular function of kidney,improve microcirculation,reduce urinary albumin and improve renal function,which is safe and effective in treating early-stage type 2 DN of Qi-Yin deficiency syndrome merged blood stasis syndrome.
出处
《新中医》
CAS
2017年第5期47-50,共4页
New Chinese Medicine
基金
杭州市卫生科技计划项目(2013B44)
