摘要
目的 探讨顺铂腹腔热灌注联合静脉化疗治疗中晚期胃癌临床疗效。方法 将82例中晚期胃癌患者按照随机数字表法均分为2组：观察组41例给予顺铂腹腔热灌注联合静脉化疗,对照组41例仅给予静脉化疗。观察近期疗效和不良反应发生情况。结果 观察组治疗总有效率为46.35%（19/41）,对照组为26.83%（11/41）,组间差异比较均有统计学意义（P〈0.05）;2组患者不良反应发生情况比较差异无统计学意义。观察组的Ig A与Ig G较对照组在治疗后提升的程度明显高,差异有统计学意义（P〈0.05）;观察组的Ig M在治疗前后与对照组差异无统计学意义。结论 给予中晚期胃癌患者顺铂腹腔热灌注联合静脉化疗,可显著提高治疗效果,不增加不良反应。
Objective To explore the cl inical efficacy of cisplat in intraper itoneal perfusion combined with intravenous chemotherapy in the reatment of advanced gastric cancer. Methods 82 cases o f patients with advanced gastric cancer were div id e d into two groups according to the random number table method： 41 cases of observation group were given cisplatin intraper itoneal perfusion combined with intravenous chemotherapy, 41 cases in he control group received intravenous chemotherapy alone. To observe the short-term curative effect and adverse reaction. Results The total effic ien c y of treatment group were 46. 35% （ 19/41） and the control group 26. 83% （ 11/41） , difference between the two groups was statistically significant （P 〈 . 05 ） ; the adverse reactions of the two groups of patients occurrence had no significant difference. Compared with the control group, the IgA and IgG in he observation group were significantly higher than that in the control group after treatment, the difference was significant （ P 〈 0. 05 ） ; there was no significant difference between the IgM group and the control group before and after treatment. Conclusion In traper itoneal perfusion combined with ntravenous chemotherapy in patients with advanced gastric cancer can significantly improve the treatment effect, without increasing adverse reactions, it s worth popularizing.
出处
《中国生化药物杂志》
CAS
2017年第4期290-292,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
局部进展期
胃癌
腹腔热灌注
静脉化疗
local advanced stage
gastric can cer
intraperitoneal p er fu s io n
intravenous chemotherapy
