摘要
目的:探讨丹参酮联合银杏叶对精神分裂伴脑梗死患者血液流变学、局部脑血流量及神经功能的影响。方法:将符合纳入标准的88例精神分裂伴脑梗死患者随机分为对照组与观察组各44例,对照组采取常规治疗,观察组在对照组基础上加以丹参酮联合银杏叶治疗,均干预4周,比较两组治疗前后精神分裂症状评分、血液流变学、局部脑血流量、神经功能缺损评分及血清自由基指标。结果:与治疗前比较,两组治疗后PANSS总分、CGI-S评分、神经功能缺损评分、全血高切黏度、全血低切黏度、血小板聚集率、纤维蛋白原、血清MDA水平均显著下降(P<0.05),且观察组治疗后上述指标均明显低于对照组(P<0.05)。观察组治疗后局部脑血流量、血清SOD水平均明显高于对照组,差异有统计学意义(P<0.05)。结论:丹参酮联合银杏叶能明显改善精神分裂伴脑梗死患者血液流变学指标,增多局部脑血流量,能显著清除氧自由基、促进患者神经功能、精神分裂症状恢复。
Objective：To investigate the effect of tanshinone combined with ginkgo leaf on hemorheology,regional cerebral blood flow and neurological function in patients with schizophrenia complicated with cerebral infarction. Methods：Eighty-eight patients with schizophrenia complicated with cerebral infarction who met with the inclusion criteria were randomized into the control group and the observation group with 44 cases in each group. Both groups were given routine therapy and the observation group was additionally treated with tanshinone and ginkgo leaf for 4 weeks. The the scores of schizophrenia symptoms,hemorheology,regional cerebral blood flow,neurological impairment scores and serum free radical indexes were compared between the two groups. Results：After treatment,PANSS scores,CGI-S scores,neurological impairment scores,whole blood high shear viscosity,whole blood low shear viscosity,platelet aggregation rates,fibrinogen and serum MDA levels were significantly lower than those before treatment（P〈0.05）,and the above indexes in the observation group were significantly lower than those in the control group while regional cerebral blood flow and serum SOD level were significantly higher（P〈0.05）. Conclusion：Tanshinone combined with ginkgo leaf can significantly improve the hemorheological indexes,increase regional cerebral blood flow,eliminate oxygen free radicals and promote the recovery of neurological function and relief of schizophrenia symptoms in patients.
出处
《辽宁中医药大学学报》
CAS
2017年第4期191-193,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
丹参酮
银杏叶
精神分裂
脑梗死
血液流变学
tanshinone
ginkgo leaf
schizophrenia
cerebral infarction
hemorheology
