摘要
[目的]分析孕妇血清C-反应蛋白浓度与妊娠期糖尿病之间的关联。[方法]选取2016年1月至2016年6月在医院接受产检的150例孕妇作为此次研究对象,根据妊娠期糖尿病筛查的结果进行分组,其中60例妊娠期糖尿病孕妇作为观察组,90例非妊娠期糖尿病孕妇作为对照组,比较两组患者血清中C-反应蛋白(CRP)的水平、空腹胰岛素水平、空腹血糖浓度、胰岛素抵抗指数等,应用多因素分析各指标与妊娠期糖尿病的相关性。[结果]两组患者在年龄、孕前体质量指数方面资料相仿,组间差异无统计学意义(P>0.05);观察组患者胰岛素抵抗指数、空腹胰岛素浓度、血清CRP含量均显著高于对照组,组间差异具有统计学意义(P<0.05);患者血清CRP水平与胰岛素抵抗指数、孕期体质量增长、体质量指数、孕前体质量均呈相关性,相关系数为0.315、0.124、0.215、0.124、0.421,经多因素分析,CRP的直线回归方程为Y=0.315X_1+0.124X_2+0.215X_3+0.124X_4+0.421X_5+1.524。[结论]C-反应蛋白是引发妊娠期糖尿病的主要危险因素,还需进一步确认是否是独立因素,在产检中定期检测CRP水平,能有效预防妊娠期糖尿病。
[Objective] To analyze the association between serum C-reactive protein and gestational diabetes mellitus. （Methods）One hundred and fifty pregnant women who were tested in our hospital from January 2016 to June 2016 were selected as the subjects. According to the results of screening for gestational diabetes mellitus, 60 pregnant women with gestational diabetes mellitus as observation group, 90 cases The levels of serum CRP, fasting insulin, fasting blood glucose and insulin resistance index were compared between the two groups. Multivariate analysis was used to analyze the relationship between the indexes and the gestational diabetes mellitus. [ Results]The insulin resistance index, fasting insulin concentration and serum CRP level in the observation group were significantly higher than those in the control group （P 〈 0.05）, but there was no significant difference between the two groups in the age, pre-pregnancy body mass index （P 〈 0.05）. The serum CRP levels were correlated with insulin resistance index, weight gain during pregnancy, body mass index and body weight before pregnancy. The correlation coefficients were 0.315, 0.124, 0.215, 0.124, 0.421, Factor analysis, CRP linear regression equation for y = 0.315X1 ＋0.124X2＋0.215X3＋0.124X4＋0.421X5＋ 1.524. [Conclusion]C-reactive protein is a major risk factor for gestational diabetes mellitus, and it is necessary to further confirm whether it is an independent factor. Regular detection of CRP level in the checkup can effectively prevent gestational diabetes mellitus.
出处
《河南大学学报（医学版）》
CAS
2017年第1期51-53,共3页
Journal of Henan University:Medical Science
