摘要
目的:探讨接骨丸对SD骨折大鼠血清钙、ALP、CD3、CD44表达的影响。方法:SD大鼠40只按照数字随机表法将其分为4个组(对照组、模型组、低剂量组、高剂量组),每组10只。模型组、低剂量组和高剂量组给予造模。对照组和模型组大鼠给予等量生理盐水灌胃;低剂量组灌胃浓度为0.4 g/kg浓度的接骨丸溶液、高剂量组灌胃浓度为1.6 g/kg的接骨丸溶液。结果:模型组、低剂量组、高剂量组治疗1周和2周血清钙、ALP、CD3、CD44水平低于对照组,模型组、低剂量组治疗3周血清钙、ALP、CD3、CD44水平低于对照组,而高剂量组治疗3周血清钙、ALP、CD3、CD44水平高于对照组(P<0.05);低剂量组和高剂量组治疗4周血清钙、ALP、CD3、CD44水平高于对照组和模型组,且高剂量组治疗4周血清钙、ALP、CD3、CD44水平高于低剂量组(P<0.05)。结论:接骨丸可能通过增加血清钙、ALP、CD3、CD44表达水平,促进骨折愈合。
Objective：To investigate the effect of Jiegu Pill on the expression of serum calcium,ALP,fracture CD3,CD44 in SD rats with fracture.Methods：Forty SD rats were randomly divided into four groups （control group,model group,low dose group, high dose group）with 10 rats in each group.Model group,low dose group and high dose group were given.Rats in the control group and the model group were given equal volume of ordinary saline and the low dose group was intragastricly administrated with Jiegu Pill solution of 0.4 g/kg concentration,while rats in the high dose group was intragastricly administrated with Jiegu Pill of 1. 6 g/kg solution.Results：The serum calcium,ALP,CD3,CD44 levels of the model group,low dose group,high dose group a week and 2 weeks later after the treatment were lower than those in the control group.serum calcium,ALP,CD3,CD44 levels of the model group and the low dose group 3 weeks after the treatment were lower than those in the control group and the high dose group,but the levels of serum were higher in the high dose group compared to those of the control group 3 weeks after the treatment （P 〈0.05）.The levels of serum calcium,ALP,CD3 and CD44 were higher in the high-dose group and low-dose group than those in the control group and the model group after 4 weeks treatment and the high-dose group was superior to the low-dose group （P 〈0.05）.Conclusion：Jiegu Pill may increase the expression of serum calcium,ALP,CD3,CD44 and promote fracture healing.
出处
《世界中医药》
CAS
2016年第12期2747-2750,共4页
World Chinese Medicine
基金
河北省科技支撑计划项目(编号:131302066)--接骨丸中士的宁
马钱子碱含量测定及肝肾毒性研究
