摘要
目的:探讨单核细胞和高密度脂蛋白胆固醇比值(MHR)与冠心病(CHD)患者冠状动脉病变程度的关系及临床意义。方法:纳入302例接受冠状动脉造影检查(CAG)的患者,根据其检查结果,将冠脉狭窄程度<50%的78例患者设为对照组(CG组),冠脉狭窄程度≥50%的224例患者设为冠心病组(CHD组),结合临床特点又分为心绞痛组(AP组)132例和急性心肌梗死组(AMI组)92例。采用Gensini评分对冠状动脉病变程度进行评分,并测定患者心肌酶、电解质、血常规、肝肾功能、血脂、空腹血糖等常规检查。结果:AMI组患者的MHR水平高于AP、CG组,AP组患者的MHR水平高于CG组,差异有统计学意义(P<0.05)。在CHD患者中MHR水平随着Gensini评分的增高逐渐递增,与Gensini评分呈正相关(r=0.39,P<0.001)。结论:MHR与冠状动脉病变程度呈正相关,在评估冠状动脉病变严重程度上有一定价值。
Objective： To investigate the correlation between monocyte to high-density lipoprotein cholesterol ratio （MHR） and severity of coronary lesion in the patients with coronary heart disease （CHD） and its clinical significance. Methods： A total of 302 patients who were examined by the coronary angiography （CAG） were enrolled. According to the result, with 78 obstructive lesion＜50% cases as controls （the CG group）. 224 cases of obstructive lesion≥50% patients were diagnosed as CHD （the CHD group）,which were further divided into two groups according to the clinical features： the angina pectoris group （the AP group,132cases） and the acute myocardial infarction group （the AMI group,92cases）.Based on on the Gensini score， the severity of coronary artery lesion ,the myocardial enzymes, electrolyte, routine blood count, liver and kidney functions, blood lipids, fasting blood glucose level and other routine checkup of patients were determined. Results： The MHR in the AMI group was highest among the three groups, and the MHR in the AP group was higher than that in the CG group, both with significant differences （P＜0.05 ）.The MHR level in CHD patients gradually elevated with the increase of Gensini score and was positively correlated with Gensini score （r =0.39, P＜0.001）. Conclusion： The MHR is positively correlated with the severity of coronary lesions. So it may be valuable for assessing the severity of coronary lesions in the patients.
出处
《天津医科大学学报》
2017年第2期157-160,共4页
Journal of Tianjin Medical University
