摘要
以2-叔丁基苯胺为起始原料,经溴代和氟化脱重氮基反应等2步操作,得到2-叔丁基-4-溴-1-氟苯,合成的产物经核磁共振谱检测确定结构。该方法起始原料廉价易得、操作简便成熟,且该化合物是合成Raf抑制剂和治疗神经退行性疾病药物的重要中间体。
The synthesis route started with 2-tert-butylbenzenamine, by way of two steps of -bromo, fluoro-de-diazotization and eventually obtained 2-tert-butyl-4-bromo-l-fluorobenzene. The structure of synthetic product was determined by nuclear magnetic resonance spectrum. The materials of this synthetic route are cheaper and easier to obtain, and the reaction procedure is also safer. This compound is the key intermediate to synthesize Raf inhibitors and a drug for the treatment of a neurodegenerative diseases.
出处
《河北北方学院学报（自然科学版）》
2017年第2期15-17,20,共4页
Journal of Hebei North University:Natural Science Edition
