摘要
目的探讨CD90在乳腺浸润性导管癌中的表达及其与临床病理特征、分子分型的相关性。方法构建80例乳腺浸润性导管癌和20例乳腺良性病变的组织芯片,采用免疫组化Max Vision法检测乳腺不同病变组织中CD90、ER、PR、Ki-67和HER-2的表达水平,并进一步分析其相关性。结果 CD90在乳腺浸润性导管癌和乳腺良性病变中的阳性率分别为62.5%和20.0%,两者差异有统计学意义(P<0.001);CD90表达与乳腺浸润性导管癌淋巴结转移相关(P<0.05),与患者年龄、肿瘤大小、TNM分期及组织学分级无关(P>0.05);在乳腺浸润性导管癌不同分子亚型中,CD90阳性率以Luminal A型最低(40.0%)、三阴型最高(82.4%),各亚型之间差异有统计学意义(P<0.05);CD90与ER(r=-0.342,P<0.05)、PR(r=-0.374,P<0.05)表达呈负相关,与Ki-67表达之间无相关性(r=0.084,P>0.05)。结论 CD90表达与乳腺癌分子分型有关,其高表达提示患者预后不良。
Purpose To detect the expression of CD90 in invasive ductal breast carcinoma with different molecular subtypes and to explore its clinical significance. Methods The expression of CD90, ER, PR, Ki-67 and HER-2 were detected in 80 cases of invasive ductal breast carcinoma tissue and 20 cases of breast benign lesion with immunohistochemical method. The relationship between CD90 and clinicopathological parameters were analyzed. Results The positive expression rate of CD90 in invasive ductal breast carcinoma and breast benign lesion tissues were 62. 5% and 20. 0% , respectively （ P 〈 0. 001 ）. The expression of CD90 in invasive ductal breast carcinoma was correlated with lymph node metastasis （ P 〈 0. 05 ）, but not with age, tumor size, TNM staging and histological grade（ P 〉 0. 05 ）. Among different molecular subtypes, CD90 expression level in Luminal A type was the lowest （40. 0% ）, and the level in triple negative type was the highest （82.4%） （P 〈 0. 05）. CD90 expression level was negatively correlated with ER （r= -0.342, P〈0.05） or PR （r = -0. 374, P 〈0.05） expression level, but not with Ki-67 （ r = 0. 084, P 〉 0. 05 ）. Conclusion The over-expression of CD90 is related with molecular subtypes of breast carcinoma, and its high expression suggests a poor prognosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2017年第3期245-249,共5页
Chinese Journal of Clinical and Experimental Pathology
基金
江西省卫生厅科技计划(20143006)
关键词
乳腺肿瘤
CD90
分子分型
转移
免疫组织化学
breast neoplasm
CD90
molecular subtyping
metastasis
immunohistochemistry
