摘要
光动力治疗(PDT),是由光敏剂(或者其纳米粒子)介导,在光的作用下,使生物分子和细胞发生形态或功能上的变化,从而诱导组织细胞损伤及坏死,被称为光敏化-氧化作用的一种非侵入治疗手段。光敏剂纳米粒子、光、单线态氧是光动力疗法的三个重要元素。目前,PDT在临床上主要应用于恶性肿瘤的治疗,具有高选择性、低毒性、微创性、靶向性好、重复治疗、治疗时间短、可与放疗和化疗协同作用等优势,在肿瘤治疗领域具有非常广泛的应用前景。根据已有文献对肿瘤的光动力治疗方法进行了综述,介绍了光敏剂(主要是纳米粒子)和光动力治疗的研究现状,展望了其未来发展方向。研究结果发现以光敏剂纳米粒子为基础的光动力治疗对肿瘤组织具有特异性吸收和滞留作用,特别对体积较小、浅表肿瘤疗效显著,对恶性肿瘤治疗也有很好的辅助作用,在肿瘤治疗领域具有广阔的应用前景。
Photodynamie therapy （PDT） is a kind of non-invasive treatment mediated by photosensitizer or its nanoparticles. Under the activation of light, the biological molecule and cell change in morphology or function, leading to cell damage and necrosis, which is also known as sensitizing light-oxidation. Photosensitizer nanoparticles, light, singlet oxygen are the vital components of PDT. At present, PDT is mainly used in the clinical treatment of malignant tumors due to its high selectivity, low toxicity, microtrauma, excellent targeting, repeated treatment, short treatment time, and it can be combined with radiotherapy and chemotherapy. In order to introduce the present situation and prospect the development of PDT, a systematic introduction about photosensitizer and PDT is presented based on the published literatures. The results show that photosensitizer nanoparticles based PDT have specific effects of penetration and retention on tumor tissue, particularly for small and shallow tumor. They also possess exciting auxiliary effect on malignant tumor. In short, PDT has broad application prospects in cancer therapy.
作者
梁平平
刘功远
董晓臣
LIANG Pingping LIU Gongyuan DONG Xiaochen(Key Laboratory of Flexible Electronics, Jiangsu National Synergetic Innovation Center for Advanced Materials, Institute of Advanced Materials, Nanjing Tech University, Nanjing 211816, China)
出处
《中国材料进展》
CAS
CSCD
北大核心
2017年第2期88-94,共7页
Materials China
基金
国家杰出青年科学基金(61525402)
关键词
光动力治疗
肿瘤
纳米粒子
光敏剂
光
单线态氧
photodynamic therapy
tumor
nanoparticles
photosensitizer
light
sing, let oxygen
