摘要
目的探讨配对母婴与不同月龄婴儿麻疹IgG抗体水平及相关性,以期为科学预防麻疹提供理论依据。方法选取鄂州市中心医院2015年1月~2016年1月收治收治的100例配对母婴为研究对象,产妇取产前静脉血、新生儿取脐带血,3月龄(85例)、5月龄(67例)、7月龄(56例)婴儿取静脉血,采用ELISA法检测血清麻疹IgG抗体,并进行统计学分析。结果新生儿麻疹IgG抗体水平[(1125.06±5.28)mU/mL]显著高于母亲[(698.31±7.89)mU/mL],差异有统计学意义(P<0.05),且新生儿麻疹IgG抗体阳性率及保护率也要显著高于母亲,差异有统计学意义(P<0.05);新生儿与母亲麻疹IgG抗体水平呈显著性正相关(r=0.743,P<0.05);麻疹自然感染史、麻疹接种史母婴麻疹IgG抗体水平显著高于无麻疹自然感染及接种史母婴,差异有统计学意义(P<0.05);新生儿麻疹IgG抗体水平显著高于3月龄、5月龄、7月龄婴儿,差异有统计学意义(P<0.05)。结论母亲麻疹IgG抗体水平是影响新生儿麻疹IgG抗体水平的重要因素,随着月龄增长婴儿抗体水平逐渐下降,应该提高育龄妇女麻疹疫苗接种率,提升低月龄婴儿母传麻疹抗体水平,增强对麻疹抵御能力。
Objective To investigate the correlation of measles IgG antibody levels in infants and mother, in order to provide theoretical basis for scientific prevention of measles. Method From January 2015 to January 2016, in Ezhou Central Hospital, 100 cases of mother and infant were selected as research object, maternal venous blood and newborn fetal cord blood were taken, 3 months old infants （85 cases）, 5 months old infants （67 cases）, 7 months old infants （56 cases） were taken the blood. The measles IgG antibody of serum were detected by ELISA. Result IgG antibody level of newborn infants [（1125.06_＋5.28） mU/mL] was significantly higher than that of mothers [（698.31_＋7.89） mU/mL], the difference was statistically significant （P 〈 0.05）, and measles IgG antibody positive rate and protection rate of newborn infants were significantly higher than those of mothers, the differences were statistically significant （P 〈 0.05）. The IgG anti- body level of measles antibody of newborn infants had significantly positive correlated with that of mothers （r = 0.743, P 〈 0.05）. Measles IgG antibody level of newborn infants and mothers with natural infection history and measles vacci- nation history were higher than thse of non measles natural infection, the differences were statistically significant （P 〈 0.05）. IgG antibody level of newborns infants was higher than those of 3 months, 5 months and 7 months old infants, the differences were statistically significant （P 〈 0.05）. Conclusion Measles IgG antibody level in mother is an impor- tant factor affecting the level of measles IgG antibody in newborn infants, with the growth of the age of the month, the antibody level of infant gradually declines, it should enhance the ability of resist measleSit by improving the measles vaccination rate of women of childbearing age.
出处
《中国医药导报》
CAS
2017年第3期113-116,共4页
China Medical Herald
基金
湖北省卫生计生指导性项目(WJ2015 Z100)
关键词
母婴
麻疹
IGG抗体
相关性
Infants and mothers
Measle
IgG antibody
Correlation
