摘要
目的探讨参苓白术散(党参、白术、茯苓,等)对结直肠癌患者术后FOLFOX化疗的减毒增效及增强免疫力方面的影响。方法将89例结直肠癌术后化疗的患者按随机数字表随机分为治疗组(45例加服参苓白术散)和对照组(44例仅化疗)。12周后,观察2组患者治疗后的临床疗效,评估证候积分,行为状况积分,检测免疫功能,毒副反应。结果治疗结束后,2组的近期疗效差异未见明显统计学意义。患者中医(TCM)证候治疗组总有效率为88.9%,对照组总有效率为70.5%,2组差异具有统计学意义。2组患者治疗后的卡氏功能状态评分(KPS评分)较治疗前均有提高,且治疗组优于对照组治疗后。治疗后治疗组的主要症状(恶心呕吐、便溏、脘腹痞满、神疲乏力)积分以及化疗引起的毒副反应(白细胞减少、中性粒细胞减少、恶心呕吐、腹痛腹泻)较对照组明显改善,治疗组治疗后CD_4^+、CD_4^+/CD_8^+均较治疗前明显升高,CD_8^+较治疗前降低,与对照组治疗后比较差异具有统计学意义。结论参苓白术散能减轻结肠癌患者术后化疗的毒副反应,增强机体免疫力。
AIM To explore the effects of toxicity reducing and synergies and immunity improvement of Shenlin Baizhu Powder（ Codonopsis Radix,Atractylodis macrocephalae Rhizoma,Poria,et al.） in the treatment of FOLFOX post-chemotheraphy patients with rectal excision. METHODS Eighty-nine patients with rectal excision were randomly divided into treatment group（ 45 cases,chemotherapy plus Shenlin Baizhu Powder） and control group（ 44 cases,only chemotherapy）. After being administered for twelve weeks,the clinical results of the two groups were observed. Symptom scores and KPS scores were evaluated; immune functions were detected; toxic and side effects were observed. RESULTS After the treatment,short-term effect of the two groups was similar without statistically significant difference. The total effective rate of TCM syndrome was 88. 9% in the treatment group and 70. 5% in the control group,respectively,the differences between them were statistically significant. KPS score was higher after the treatment than that before the treatment in both groups,and KPS score was better in the treatment group than that in the control group. After the treatment,the main symptom scores（ nausea and vomiting,diarrhea,abdominal fullness,lassitude） and toxic and side effects caused by chemotherapy（ white blood cells and neutrophils redused,nausea and vomiting,abdominal pain,diarrhea） in the treatment group were better improved than those in the control group. After the treatment,levels of CD4^＋ and CD4^＋/ CD8^＋ in the treatment group were obviously higher than those before the treatment,but level of CD8^＋ was lower than that before the treatment.There were significant differences of statistics between the two groups. CONCLUSION Shenlin Baizhu Powder can reduce toxic and side-effects caused by chemotherapy and enhance immunity.
出处
《中成药》
CAS
CSCD
北大核心
2017年第2期278-282,共5页
Chinese Traditional Patent Medicine
基金
国家自然科学基金资助项目(81273745)
天津市自然科学基金(11JCYBJC10900)
关键词
参苓白术散
结直肠癌切除
化疗
免疫功能
毒副反应
Shenlin Baizhu Powder
rectal excision
chemotherapy
immune function
toxic and side effect
