摘要
目的探讨金属蛋白酶8(MMP-8)基因C-799T多态性位点与自发性早产遗传易感性的关联性。方法病例组样本包括753例自发性早产(SPTB)新生儿,对照组包括681例足月新生儿。采用最新的Sequenom MassARRAY?SNP检测技术对MMP-8基因C-799T多态性位点进行SNP分型。结果与携带MMP-8基因C-799T多态性位点CC基因型的个体相比,携带至少一个-799T等位型(CT+TT基因型)的个体发生SPTB、合并PROM的SPTB(PPROM)以及轻度早产的风险显著降低。与携带至少一个C等位型(CC+CT基因型)的个体相比,TT基因型与不合并PROM的SPTB的患病风险的降低有临界的相关性。结论 MMP-8基因C-799T多态性位点可以影响SPTB的遗传易感性。
Objective To investigate the association between the genetic polymorphisms of MMP-8C-799 Tand susceptibility to spontaneous preterm birth（SPTB）. Methods This case-control study enrolled 753 SPTB singleton neonates and 681 term neonates.Polymorphism was genotyped using Sequenom MassARRAY？SNP. Result Compared with the CC genotypes,MMP-8-799T-positive genotypes（CT＋TT genotypes）were significantly associated with a decreased susceptibility to SPTB and moderate SPTB.The-799T-positive genotypes（CT＋TT genotype）were also significantly associated with decreased SPTB susceptibility in preterm neonates with PROM.Comparing with the CC ＋ CT genotypes,-799 TT genotype was marginally associated with a decreased SPTB susceptibility in preterm neonates without PROM. ConclusionMMP-8C-799 Tcontributes to the SPTB susceptibility.
出处
《中国儿童保健杂志》
CAS
2017年第2期112-116,共5页
Chinese Journal of Child Health Care
基金
国家自然科学基金(81300527)
关键词
金属蛋白酶-8
自发性早产
胎膜早破
单核苷酸多态性
matrix metalloproteinases-8
spontaneous preterm birth
premature rupture of membranes
single nucleotide polymorphisms
