摘要
目的探讨糖尿病患者体质量指数(BMI)水平与高血压发病的关系。方法 2 367例糖尿病患者,按2006年6月~2007年10月体检时基线BMI分为非肥胖组(BMI<28 kg/m^2)、肥胖组(BMI≥28 kg/m^2),并按基线BMI四分位数分为<23、23~<25、25~<27、≥27 kg/m^2,2008年6月~2009年10月体检时观察不同BMI糖尿病患者高血压发病率。采用多因素Logistic回归模型分析糖尿病患者BMI水平与高血压发病风险之间的关系。结果2 367例糖尿病患者高血压的发病率为38.36%,男性高血压发病率(40.21%)高于女性(31.03%),P<0.05。肥胖组高血压发病率(48.91%)高于非肥胖组(35.83%),P<0.01。BMI为<23、23~<25、25~<27、≥27 kg/m^2高血压的发病率分别为29.83%、36.15%、40.81%、46.62%,四者相比P<0.01;按男女性别进行分层后,男性高血压的发病率分别为32.06%、37.45%、43.51%、47.63%,四者相比P<0.01;女性高血压的发病率分别为22.92%、28.89%、29.57%、42.97%,四者相比P<0.01。单因素分析显示,BMI为23~<25、25~<27、≥27 kg/m^2总体高血压发病风险分别是BMI<23 kg/m^2的1.332、1.622和2.055倍;BMI≥27 kg/m^2女性OR值为2.534;BMI为25~<27、≥27 kg/m^2男性的OR值分别为1.632和1.927。多因素Logistic回归分析显示,校正年龄、收缩压等因素后,与BMI<23 kg/m^2比较,BMI为25~<27 kg/m^2总体和男性的OR值为1.400、1.412,BMI≥27 kg/m^2总体、男性和女性的OR值为1.729、1.596和2.636。结论 BMI是糖尿病患者高血压发病的危险因素,BMI对男性糖尿病患者高血压发病的影响较女性大。
Objective To explore the relationship between body mass index （BMI） and the new-onset hypertension in diabetic patients. Methods According to the baseline BMI measurement from June 2006 to October 2007, 2 367 diabetic patients were divided into the obese group （BMI 〈 28 kg/m2） and non-obese group （BMI ≥28 kg/m2）, and in accordance with the baseline BMI quartile, they were divided into groups with BMI 〈 23, 23- 〈 25, 25- 〈 27 and I〉27 kg/m2. During June 2008 to October 2009, a repeated health examination was carried out to observe the incidence of hypertension in dia- betic patients with different BMI. Multiple Logistic regression analysis was used to test the BMI level and the hypertension. Results （1） The incidence rate of hypertension was 38.36% in 2 367 diabetic patients, and the incidence rate in males （40.21%） was higher than that in females （31.03%）, （P 〈0.05 ）. The incidence of hypertension was higher in the obese group （48.91%） ihan that （35.83%） in the non-obese group（P 〈0.01 ）. The incidence rates of hypertension in patients with BMI 〈23, 23- 〈25, 25- 〈27 and I〉27 kg/m2 were 29.83%, 36.15%, 40.81% and 46.62%, respectively, and significant difference was found between them （ P 〈 0.01 ）. After the stratification by gender, the incidence rates of hypertension in males were 32.06% , 37.45%, 43.51% and 47.63 % 1 respectively （P 〈 0. 01 ）. The incidence rates of hypertension in females were 22.92%, 28.89% , 29.57% and 42.97%, respectively （P 〈0.01 ）. @ Univariate analysis showed that the overall risk of hypertension odds ratio （OR） was 1. 332, 1. 622 and 2.055 in patients with BMI 23- 〈 25, 25- 〈 27 and ≥27 kg/m2 as compared with that with BMI 〈 23 kg/m2. The OR value was 2.534 for females with BMI ≥27 kg/m2, and 1. 632 and 1. 927 for males with BMI of 25-27 and ≥27 kg/m2 , respectively. Multivariate Logistic regression analysis showed that after adjustment for age, systolic blood pressure and other factors, the OR for all and males with BMI of 25-27 kg/m2 were 1. 400, 1. 412, the OR values for all, males and females with BMI≥27 kg/m2 were 1. 729, 1. 596, and 2. 636 as compared with those of the patients with BMI 〈 23 kg/m2. Conclusion BMI may be an risk factor for the new-onset hypertension in diabetic patients, and BMI has a greater impact on the incidence of hypertension in male diabetic patients.
出处
《山东医药》
CAS
北大核心
2017年第2期25-28,共4页
Shandong Medical Journal
基金
河北省医学科学研究重点课题计划项目(20110632)
关键词
糖尿病
体质量指数
高血压
diabetes mellitus
body mass index
hypertension
