摘要
目的了解育龄期妇女乙肝病毒(HBV)感染状况及基因分布特点。方法按分层整群随机抽样原则,抽取泉州乙肝高流行区15~59岁育龄期妇女1 859人,对调查对象进行问卷调查及血标本采集检测。结果检测1 859份血清标本,其中HBsAg、抗-HBs、HBe Ag、抗-HBe、抗-HBc阳性率分别为9.6%、65.8%、17.3%、63.7%、7.2%。HBsAg单阳性占8.0%,HBsAg、HBe Ag双阳性占7.4%;HBsAg阳性率沿海高于内地(P<0.05);15岁~组明显低于30岁~、40岁~组;医务人员及公共服务人员较低,干部较高。自诉接种过Hep B疫苗的占28.2%,免疫失败率为7.1%。接种Hep B疫苗的育龄期妇女HBsAb阳性率(73.1%)明显高于无免疫接种(60.3%)。179例HBsAg阳性血标本HBV-DNA载量阳性72例,其中载量>106拷贝/m L占16.8%。对HBV-DNA载量阳性进行基因分型,其中B型占66.7%,C型25.0%,D型1.4%,B/C混合型1.4%,基因未定型5.6%,未见A、E、F型。南安与晋江相比,B型占多数,C型较少。结论福建省乙肝高流行区育龄期妇女HBsAg携带率处于较高水平,小年龄组HBsAg携带较低,基因型以B型为主,Hep B疫苗接种预防效果显著,仍需继续落实HBV母婴阻断干预措施。
Objective To understand the status of hepatitis B virus（HBV） infection and distribution characteristics ofgenes among women at childbearing age in Fujian Province. Methods By the stratifying cluster random sampling principle,1 859 childbearing women aged 15 to 59 years in HBV high prevalence areas of Quanzhou were sampled as research objectsand investigated with questionnaires, and their blood samples were collected and detected. Results The positive rates ofHBsAg, Anti-HBs, HBe Ag, Anti-Hbe, and Anti-HBc were 9.6%, 65.8%, 17.3%, 63.7%, and 7.2%, respectively,in all 1 859 sumples. In all the survey respondents, the single positive rate of HBsAg was 8.0%, and double positives rate of HBsAg andHBe Ag was 7.4%. The HBsAg positive rate in coastal area was significantly higher than that in hinterland（P 0.05）. TheHBsAg positive rate of the 15-year-old group was significantly lower than the ratest of the 30 and 40 year-old groups. TheHBsAg positive rate of medical personnel and public service personnel was low, but that of cadres was high. The rate of personswho depicted vaccination of hepatitis B vaccine（Hep B） was 28.2%, and the rate of failure immunization was 7.1%. The HBsAbpositive rate of women at childbearing age who had Hep B vaccination was 73.1%, which was significantly higher than that ofthe women without vaccination（60.3%）. Among 179 HBsAg positive blood samples, 72 cases of HBV-DNA load were positive,wherein the load〉106copies/m L accounted for 16.8%. Genotyping for positive HBV-DNA load, B-type was 66.7%, C-type was25.0%, D-type was 1.4%, B and C mixed type was 1.4%, and undifferentiated gene was 5.6%, but A, E, and F types were notdiscovered. Compared to Jinjiang City, B-type was majority, and C-type was smaller in Nan＇an Country. Conclusions Thepositive rate of HBsAg among women at childbearing age is high in HBV highly endemic area of Fujian Procince. The positiverate of HBsAg of the younger age group is low, and the genotype B is the main type. Hep B vaccine inoculation has a significanteffect, and we should continue to implement the interventions to block the HBV mother-to-child transmission（MTCT）.
作者
张苏晗
杨秀惠
陈致飞
李东
黄丽芳
陈俊磊
潘伟毅
郑凝旋
张红榕
周勇
ZHANG Suhan YANG Xiuhui CHEN Zhifei LI Dong HUANG Lifang CHENG Junlei PAN Weiyi ZHENG Ningxuan ZHANG Hongrong ZHOU Yong(Center for Disease Control and Prevention in Fujian, Fuzhou, Fujian 351000, China)
出处
《中国热带医学》
CAS
2017年第1期59-63,共5页
China Tropical Medicine
基金
国家科技重大专项课题(No.2012ZX10002001-002-002
2016ZX10002001-002-004
2016ZX10002001-002-005)
福建省卫生厅青年科研课题(No.2014-2-10)
