摘要
目的研究慢性阻塞性肺疾病（COPD）合并重症呼吸衰竭老年患者采用无创正压通气（NIPPV）治疗的临床效果。方法 128例COPD合并重症呼吸衰竭老年患者,按随机数字表法分为对照组和观察组,各64例。对照组患者采用常规内科药物治疗,观察组患者在对照组治疗基础上联合NIPPV治疗。观察两组患者治疗效果、血气情况、肺功能以及并发症发生情况。结果观察组治疗总有效率为96.88%,高于对照组的85.94%,差异具有统计学意义（χ~2=4.873,P〈0.05）。治疗后,观察组心率（HR）、呼吸频率（RR）、动脉血氧分压（PaO_2）以及动脉血二氧化碳分压（PaCO_2）水平均明显优于对照组,差异具有统计学意义（P〈0.05）。治疗后,观察组第一秒用力呼气容积（FEV1）、用力肺活量（FVC）水平明显优于对照组,差异具有统计学意义（P〈0.05）。观察组并发症发生率为9.38%,对照组为6.25%,比较差异无统计学意义（P〉0.05）。结论 NIPPV治疗COPD合并重症呼吸衰竭患者效果显著,明显改善呼吸功能和肺功能,不增加并发症发生率,值得临床应用及推广。
Objective To research clinical effect by non- invasive positive pressure ventilation（NIPPV）in the treatment of senile patients of chronic obstructive pulmonary disease（COPD） complicated with severe respiratory failure.Methods A total of 128 senile patients of COPD complicated with severe respiratory failure were divided by random number table into control group and observation group,with 64 cases in each group.The control group received conventional internal medication for treatment,and the observation group also received NIPPV for combined treatment.Observation was made on curative effect,blood gas condition,pulmonary function and complications in both groups.Results The observation group had total effective rate as 96.88%,which was higher than 85.94%in the control group,and the difference had statistical significance（χ~2=4.873,P〈0.05）.After treatment,the observation group had all better hear rate（H R）,respiratory rate（RR）,arterial partial pressure of oxygen（PaO_2） and arterial partial pressure of carbon dioxide（PaCO_2） levels than the control group,and their difference had statistical significance（P〈0.05）.After treatment,the observation group had better forced expiratory volume in 1 second（FEV1） and forced vital capacity（FVC） levels than the control group,and their difference had statistical significance（P〈0.05）.The observation group had incidence of complications as 9.38%,and the control group had that as 6.25%.Their difference had no statistical significance（P〈0.05）.Conclusion NIPPV shows precise effect in treating COPD complicated with severe respiratory failure patients.This method can remarkably imprcve respiratory and pulmonary function,without increased incidence of complications.It is worth clinical application and promotion.
出处
《中国实用医药》
2016年第33期28-30,共3页
China Practical Medicine
关键词
慢性阻塞性肺疾病
呼吸衰竭
无创正压通气
疗效
Chronic obstructive pulmonary disease
Respiratory failure
Non-invasive positive pressure ventilation
Curative effect
