摘要
炎症是一种机体对感染或组织损伤的保护性反应。适度的或可控的炎症对于入侵病原微生物的清除以及受损组织的修复是必需的,然而过度的或不可控的炎症往往会导致病理性炎症反应发生,大大提高了各种感染性和代谢性疾病的发病风险。多不饱脂肪酸代谢生成的脂质调控介质对炎症的启动、发展以及消退均具有重要的调节作用,了解多不和脂肪酸的代谢及其代谢产物对炎症反应的调节机制,对于通过饲粮营养途径控制疾病发生以及改善人和动物健康具有重要的理论和现实意义。鉴此,本文综述了多不饱和脂肪酸的代谢途径,并就其代谢产物对炎症反应的调节进行了详细论述。
Inflammation is part of protective response to infection or tissue injury. Appropriate or controlled inflammation is necessary to eliminate invading pathogens and repair damaged tissue. However,excessive or uncontrolled inflammation contributes to a range of pathological inflammatory responses,which may result in the increased incidence of both metabolic and infectious diseases. Lipid mediators derived from polyunsaturated fatty acids have important roles in regulating the initiation,development and resolving of inflammatory responses.A better understanding of the metabolism of polyunsaturated fatty acids and its regulation to inflammation will facilitate the development of dietary nutritional strategies to control the incidence of diseases and improve human and animal health. Therefore,the metabolic pathways of polyunsaturated fatty acids and the regulatory mechanism of its metabolic products to inflammation were reviewed in this paper.
出处
《动物营养学报》
CAS
CSCD
北大核心
2017年第1期1-7,共7页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金项目(31560644)
内蒙古自然科学基金项目(2015MS0367)
引进高层次人才科研启动经费项目(2015YJRC005)
关键词
多不饱和脂肪酸
代谢
脂质调控介质
炎症
polyunsaturated fatty acids
metabolism
lipid mediators
inflammation
