摘要
随着胰岛素治疗2型糖尿病研究的不断深入,其引起的安全性问题需要引起重视。即使在2型糖尿病晚期仍然可以使用其他治疗方式来替代胰岛素治疗,过度强化血糖治疗,并不会增加患者远期存活率,而且胰岛素治疗可能会增加心血管事件的致死风险。通过对比英国的前瞻性糖尿病研究、控制糖尿病心血管风险行动的研究及甘精胰岛素初始干预转归等临床研究结果,可对胰岛素治疗的安全性进行充分的再评估。
With the continuous development of insulin therapy in type 2 diabetes mellitus, the safety problems caused by insulin therapy need to be paid attention to. Though in advanced type 2 diabetes, other treatments can be used to replace insulin therapy,intensive insulin therapy does not increase the long-term survival rate of the patients, and insulin therapy may increase the risk of death from cardiovascular events. Here is to compared the results of clinical trials such as UK Prospective Diabetes Study（UKPDS） , Action to Control Cardiovascular Risk in Diabetes （ACCORD）, and Outcomes Reduction with an Initial Glargine Intervention（ ORIGIN）, to fully reassess the safety of insulin therapy.
作者
贺克强
柴小青
李卫平
HE Keqiang CHAI Xiaoqing LI Weiping(Department of Pharmacology, College of Basic Medicine, Anhui Medical University, Hefei 230032, China Department of Anesthesiology,Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China Department of Pharmacology ,Anqing Medical and Pharmaceutical College ,At u ling 246000, China)
出处
《医学综述》
2017年第1期112-115,共4页
Medical Recapitulate
基金
高等学校博士学科点专项科研基金(20123420110004)
关键词
高胰岛素血症
外源性胰岛素
降糖药
心血管事件
Hypefinsulinemia
Exogenous insulin
Hypoglycemic agents
Cardiovascular events
