摘要
目的探讨检测血清同型半胱氨酸(Hcy)、D-二聚体(D-D)及纤维蛋白原(FIB)在慢性阻塞性肺疾病(慢阻肺)急性加重期合并2型糖尿病(T2DM)患者中的临床意义。方法选取我院收治的慢阻肺急性加重期合并T2DM患者79例为观察组,按就诊顺序1:1比例随机抽取同期住院的慢阻肺急性加重期不合并T2DM患者79例对照组,两组入院后均检测空腹血糖(FBS)、糖化血红蛋白(HbA1c)、血气分析、Hcy、D-D及FIB,并计算氧合指数(OI)。结果(1)观察组在性别、年龄、慢阻肺病程、合并症及血压等一般资料与对照组相比差异均无统计学意义(P>0.05);(2)观察组PH值及OI均低于对照组,动脉血二氧化碳分压高于对照组(P<0.01);(3)观察组血清FBS、HbA1c、Hcy、D-D及FIB水平均高于对照组(P<0.01)。结论慢阻肺急性加重期合并T2DM的患者通过检测血清Hcy、D-D及FIB水平可以了解患者高凝状态和血栓前状态的严重程度,对制定治疗方案、观察疗效、判断预后有广泛的应用价值。
Objective To investigate the clinical significance of detecting serum homocysteine （ Hcy）, D- dimer （D-D） and fibrinogen （FIB） in patients with AECOPD complicated with type 2 diabetes mellitus （T2DM）. Methods 79 AECOPD patients complicated with T2DM in our hospital were selected as the observation group. According to the order of 1 ： 1, the proportion of AECOPD without T2DM was randomly selected from the same period as the control group. Fasting blood glucose （FBS）, glycosylated hemoglobin （HbA1 c）, blood gas analysis, D-D, FIB and Hcy were detected in the two groups, and the oxygenation index （OI） was calculated. Results （1） There was no significant difference in sex, age, COPD duration, and blood pressure between the two groups （ P 〉 0. 05 ）. （2） The value of pH and OI was lower in the observation group than in the control group, and arterial blood carbon dioxide partial pressure was higher than that of the control group （ P 〈 0. 01 ）. （3） The levels of serum FBS, Hcy, HbA1 c, D- D and FIB in the observation group were higher than those in the control group （P 〈 0.01 ）. Conclusion The detection of Hcy, D-D and FIB in AECOPD patients complicated with T2DM can be used to understand the severity of patients with high blood coagulation status and the degree of pre-thrombosis state, which helps to develop treatment plans and observe the curative effect.
出处
《临床肺科杂志》
2017年第2期325-328,共4页
Journal of Clinical Pulmonary Medicine
